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Uncategorized Published - 27 September, 2023    By - Dr Clemens
Anesthesia and Sedation Exposure and Neurodevelopmental Outcomes in Infants Undergoing Congenital Cardiac Surgery

Authors: Allan F. Simpao, M.D., M.B.I. et al  Anesthesiology October 2023, Vol. 139, 393–404. Background Children undergoing complex cardiac surgery are exposed to substantial cumulative doses of sedative medications and volatile anesthetics and are more frequently anesthetized with ketamine, compared with healthy children. This study hypothesized that greater exposure to sedation and anesthesia in this population […]

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Uncategorized Published - 27 September, 2023    By - Dr Clemens
Health Inequity: Too Expensive for Anyone and Everyone

Author: Adaora M. Chima, MBBS, MPH IARS Newsletter Issue 4 Health inequity and health disparity are phrases that have grown in medical, scientific and secular use in recent years. Although often used interchangeably, these pervasive issues are distinct but interwoven complex phenomena that have a ripple effect on every single member of societies where they […]

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Uncategorized Published - 26 September, 2023    By - Dr Clemens
REGIONAL ANESTHESIA FOR PATIENTS WITH IMPLANTED PERIPHERAL NERVE STIMULATORS: TO DO OR NOT TO DO

American Society for Post Surgical Pain 01 Newsletter ABSTRACT Peripheral nerve stimulation (PNS) is a relatively novel therapeutic intervention that has been gaining popularity in the management of various chronic pain conditions. The new intervention has shown promising results with a narrow risk margin for complication and has gained US Food and Drug Administration (FDA) […]

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Uncategorized Published - 26 September, 2023    By - Dr Clemens
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling

AUTHORS: Chen, Zhao-Rong MM et al  Anesthesia & Analgesia 137(2):p 426-439, August 2023. BACKGROUND: Myocardial infarction is a common perioperative complication, and blood flow restoration causes ischemia/reperfusion injury (IRI). Dexmedetomidine (DEX) pretreatment can protect against cardiac IRI, but the mechanism is still insufficiently understood. METHODS: In vivo, myocardial ischemia/reperfusion (30 minutes/120 minutes) was induced via ligation […]

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Uncategorized Published - 26 September, 2023    By - Dr Clemens
Combined Arterial Hypertension and Ischemic Stroke Exaggerate Anesthesia-Related Hypotension and Cerebral Oxygenation Deficits

AUTHORS: Zhang, Tracy MD et al Anesthesia & Analgesia 137(2):p 440-450, August 2023. Background: Intraoperative arterial hypotension (IOH) is a common side effect of general anesthesia (GA), associated with poor outcomes in ischemic stroke. While IOH is more prevalent with hypertension, it is unknown whether IOH may differ when GA is induced during ischemic stroke, versus […]

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