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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest

Authors: Glenn Eastwood et al N Engl J Med 2023 Jul 6;389(1):45-57. Background: Guidelines recommend normocapnia for adults with coma who are resuscitated after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow and may improve neurologic outcomes. Methods: We randomly assigned adults with coma who had been resuscitated after out-of-hospital cardiac arrest of presumed cardiac […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Opioid analgesia for acute low back pain and neck pain (the OPAL trial)

Authors: Caitlin M P Jones et al Lancet. 2023 Aug 19;402(10402):612 Background: Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and neck pain. […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage

Authors: Stefan Wolf et al JAMA Neurol 2023 Aug 1;80(8):833-842. Importance: After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease the incidence of delayed cerebral ischemia and improve long-term outcome. Objective: To determine the effectiveness of early lumbar cerebrospinal fluid drainage added to standard of care in patients after aneurysmal subarachnoid hemorrhage. […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Association of Genetic Variants with Postsurgical Pain

Authors: Stephan G. Frangakis, M.D., Ph.D. et al  Anesthesiology September 2023. Background Postsurgical pain is a key component of surgical recovery. However, the genetic drivers of postsurgical pain remain unclear. A broad review and meta-analyses of variants of interest will help investigators understand the potential effects of genetic variation. Methods This article is a systematic […]

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Uncategorized Published - 16 October, 2023    By - Dr Clemens
Evaluation of malignant hyperthermia features in patients with pathogenic or likely pathogenic RYR1 variants disclosedthrough a population genomic screening program

Authors: Kristen D. Yu, M.S. et al  Anesthesiology October 2023. Background Malignant hyperthermia (MH) susceptibility is a heritable musculoskeletal disorder that can present as a potentially fatal hypermetabolic response to triggering anesthesia agents. Genomic screening for variants in MH-associated genes RYR1 and CACNA1S provides an opportunity to prevent morbidity and mortality. There are limited outcomes data from disclosing variants […]

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