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Authors: Kuai S et al. Anesthesiology. December 2025. DOI: 10.1097/ALN.0000000000005897 SummaryThis preclinical study investigated how noradrenergic signaling from the locus coeruleus (LC) modulates pain sensitivity through interactions with the paraventricular thalamic nucleus (PVA) and the anterior cingulate cortex (ACC). While LC projections to both the thalamus and cortex have been implicated in pain processing, the […]
Read MoreAuthors: Jansen S et al. Anesthesiology. December 2025. DOI: 10.1097/ALN.0000000000005894 SummaryThis randomized, double-blind, placebo-controlled study compared the respiratory and antinociceptive effects of the dual nociceptin–mu opioid receptor (NOP–MOP) agonist cebranopadol with the full mu-opioid receptor agonist oxycodone in healthy volunteers. The rationale for the study stems from preclinical and early clinical data suggesting that NOP […]
Read MoreAuthor: Cameron Cortigiano Becker’s ASC Review The lack of reimbursements, staffing shortages and cost challenges are some of the biggest hurdles for anesthesia providers and groups heading into next year. Two leaders recently connected with Becker’s to share what they believe will be the toughest challenges for the anesthesia space in 2026. Note: Responses were lightly edited […]
Read MoreHardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]
Read MoreAuthor: Dr Rob Clemens As the year comes to a close, we want to take a moment to say thank you and wish you and your family a very Merry Christmas. In anesthesia and healthcare, the holidays rarely mean a full stop. Patients still need care, operating rooms still run, and teams continue to show […]
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