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Uncategorized Published - 26 June, 2024    By - Dr Clemens
Insurance-based Disparities in Outcomes and Extracorporeal Membrane Oxygenation Utilization for Hospitalized COVID-19 Patients

Authors: Laurent G. Glance, M.D. et al  Anesthesiology July 2024, Vol. 141, 116–130. Background The objective of this study was to examine insurance-based disparities in mortality, nonhome discharges, and extracorporeal membrane oxygenation utilization in patients hospitalized with COVID-19. Methods Using a national database of U.S. academic medical centers and their affiliated hospitals, the risk-adjusted association between […]

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Uncategorized Published - 26 June, 2024    By - Dr Clemens
Nerve Injury Triggers Time-dependent Activation of the Locus Coeruleus, Influencing Spontaneous Pain-like Behavior in Rats

Authors: Irene Suárez-Pereira, Ph.D. et al  Anesthesiology July 2024, Vol. 141, 131–150. Background Dynamic changes in neuronal activity and in noradrenergic locus coeruleus (LC) projections have been proposed during the transition from acute to chronic pain. Thus, the authors explored the cellular cFos activity of the LC and its projections in conjunction with spontaneous pain-like behavior […]

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Uncategorized Published - 26 June, 2024    By - Dr Clemens
Sweeping Away Dyspnea

Authors: Nikolaos J. Skubas, M.D., D.Sc., F.A.C.C., F.A.S.E. et al  Anesthesiology July 2024, Vol. 141, 10–12. “[A] multicomponent assessment of dyspnea is important in awake venoarterial ECMO patients.” In this issue of Anesthesiology, Bureau et al.  delineate the characteristics and treatment of dyspnea in a unique cohort of patients, namely spontaneously breathing patients with cardiogenic shock receiving modest […]

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Uncategorized Published - 26 June, 2024    By - Dr Clemens
Science, Medicine, and the Anesthesiologist

Author: Charles Emala, M.D. Anesthesiology July 2024, Vol. 141, A13–A15. Capillary oxygen regulates demand-supply coupling by triggering connexin40-meidated conduction: Rethinking the metabolic hypothesis. Proc Natl Acad Sci USA 2024; 121:e2303119121. PMID: 38349880. Tissue oxygen delivery requires localized sensing of oxygen demand that dictates upstream arteriolar dilation. Microvascular blood flow is closely matched to tissue oxygen requirements […]

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Uncategorized Published - 25 June, 2024    By - Dr Clemens
Effects of an Early Intensive Blood Pressure–lowering Strategy Using Remifentanil and Dexmedetomidine in Patients with Spontaneous Intracerebral Hemorrhage

Authors: Rui Dong, M.M. et al  Anesthesiology July 2024, Vol. 141, 100–115. Background Although it has been established that elevated blood pressure and its variability worsen outcomes in spontaneous intracerebral hemorrhage, antihypertensives use during the acute phase still lacks robust evidence. A blood pressure–lowering regimen using remifentanil and dexmedetomidine might be a reasonable therapeutic option given […]

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