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Uncategorized Published - 4 March, 2024    By - Dr Clemens
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier

AUTHORS: Wang, Yu MD et al  Anesthesia & Analgesia November 23, 2023. | BACKGROUND: Dysfunction of the blood-spinal cord barrier (BSCB) contributes to the occurrence and development of neuropathic pain (NP). Previous studies revealed that the activation of cyclophilin A (CypA)-metalloproteinase-9 (MMP9) signaling pathway can disrupt the integrity of the blood-brain barrier (BBB) and aggravate neuroinflammatory […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Daily marijuana use increases heart failure risk by 34%

Author: Michael Walter Cardiovascular Business Regular marijuana use may significant increase a person’s risk of developing heart failure, according to new research presented at the American Heart Association’s Scientific Sessions 2023 in Philadelphia. “Prior research shows links between marijuana use and cardiovascular disease like coronary artery disease, heart failure and atrial fibrillation, which is known to cause heart […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Artificial Intelligence in Anesthetic Care

AUTHORS: Estrada Alamo, Carlos E. MD, MBA et al   Anesthesia & Analgesia December 07, 2023. BACKGROUND: This study explored physician anesthesiologists’ knowledge, exposure, and perceptions of artificial intelligence (AI) and their associations with attitudes and expectations regarding its use in clinical practice. The findings highlight the importance of understanding anesthesiologists’ perspectives for the successful integration […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Quercetin, Main Active Ingredient of Moutan Cortex, Alleviates Chronic Orofacial Pain via Block of Voltage-Gated Sodium Channel

AUTHORS: Liu, Zhanli MD et al  Anesthesia & Analgesia November 17, 2023. BACKGROUND: Chronic orofacial pain (COP) therapy is challenging, as current medical treatments are extremely lacking. Moutan Cortex (MC) is a traditional Chinese medicine herb widely used for chronic inflammatory diseases. However, the mechanism behind MC in COP therapy has not been well-established. The […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Low Perfusion and Missed Diagnosis of Hypoxemia by Pulse Oximetry in Darkly Pigmented Skin

AUTHORS: Gudelunas, M. Koa BS et al  Anesthesia & Analgesia 138(3):p 552-561, March 2024. BACKGROUND: Retrospective clinical trials of pulse oximeter accuracy report more frequent missed diagnoses of hypoxemia in hospitalized Black patients than White patients, differences that may contribute to racial disparities in health and health care. Retrospective studies have limitations including mistiming of blood […]

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