⭐ Recognized by FeedSpot: #12 Best Anesthesiology Blog Worldwide

Uncategorized Published - 7 March, 2024    By - Dr Clemens
Movement-evoked Pain versus Pain at Rest in Postsurgical Clinical Trials and in Meta-analyses

Authors: Ian Gilron, M.D., M.Sc., F.R.C.P.C. et al  Anesthesiology March 2024, Vol. 140, 442–449. Background Given the widespread recognition that postsurgical movement-evoked pain is generally more intense, and more functionally relevant, than pain at rest, the authors conducted an update to a previous 2011 review to re-evaluate the assessment of pain at rest and movement-evoked pain […]

Read More
Uncategorized Published - 7 March, 2024    By - Dr Clemens
Effect of an Individualized Lung Protective Ventilation on Lung Strain and Stress in Children Undergoing Laparoscopy

Authors: Cecilia M. Acosta, M.D. et al  Anesthesiology March 2024, Vol. 140, 430–441. Background Exaggerated lung strain and stress could damage lungs in anesthetized children. The authors hypothesized that the association of capnoperitoneum and lung collapse in anesthetized children increases lung strain-stress. Their primary aim was to describe the impact of capnoperitoneum on lung strain-stress and […]

Read More
Uncategorized Published - 7 March, 2024    By - Dr Clemens
In Vitro Model of Prepacked Carbon Dioxide Absorber Use

Authors: Jennifer Jouwena, M.D. et al Anesthesiology March 2024, Vol. 140, 450–462. Background Carbon dioxide absorbers allow the use of fresh gas flow below minute ventilation (⁠V˙E⁠). Models are developed and tested in vitro to quantify their performance with variable carbon dioxide load (⁠V˙CO2⁠), fresh gas flow, V˙E⁠, end-tidal carbon dioxide (ETco2) fraction, and the type of workstation used. […]

Read More
Uncategorized Published - 7 March, 2024    By - Dr Clemens
Isoflurane Inhibits the Na+/K+-ATPase: Reply

Authors: Clemens Reiffurth, Ph.D. et al  Anesthesiology March 2024, Vol. 140, 635–636. In Reply: We thank Dr. Enlund very much for his comments and motivating words.  The interactions of anesthetics with key mechanisms in energy metabolism and ion homeostasis occur simultaneously as we observed in our experiments.  These complex interactions might be relevant for both neuroprotection and neurotoxicity […]

Read More
Uncategorized Published - 7 March, 2024    By - Dr Clemens
Astrocytes: Dual Roles in Chronic Pain and Memory Formation

Author: Vivianne L. Tawfik, M.D., Ph.D.  Anesthesiology March 2024, Vol. 140, 358–360. “[…] these experiments nicely demonstrate that CA1 astrocytes, and their L-lactate release, are both necessary and sufficient for pain modulation and memory formation.” Astrocytes are glial cells, abundant in the central nervous system, that form a highly interconnected and organized network of cells.  They make […]

Read More