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Uncategorized Published - 14 March, 2024    By - Dr Clemens
Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord

Authors: Bing Wang, Ph.D. et al  Anesthesiology March 2024, Vol. 140, 558–577. Background Endoplasmic reticulum stress plays a crucial role in the pathogenesis of neuroinflammation and chronic pain. This study hypothesized that PRKR-like endoplasmic reticulum kinase (PERK) and inositol-requiring enzyme type 1 (IRE1) regulate lipocalin-2 (LCN2) and Nod-like receptor family pyrin domain containing 3 (NLRP3) expression […]

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Uncategorized Published - 13 March, 2024    By - Dr Clemens
Biden’s $7.3 trillion budget: 16 healthcare takeaways

Authors: Madeline Ashley, Kelly Gooch and Alexis Kayser Becker’s Hosptial CFO Report President Joe Biden proposed a $7.3 trillion budget March 11, including various initiatives to lower healthcare costs and an $800 million investment in hospital cybersecurity protection. 16 healthcare takeaways: 1. Medicare. The proposed budget would extend the solvency of the Medicare hospital insurance trust fund indefinitely. […]

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Uncategorized Published - 13 March, 2024    By - Dr Clemens
Too Good to Be True?

Author: Keith H. Baker, M.D., Ph.D. Anesthesiology March 2024, Vol. 140, 634. To the Editor: It was a pleasure to see a letter to the editor in Anesthesiology that mentioned the learning advantage of pictures compared to words.  This advantage is known as the picture superiority effect. I was skeptical of the stated learning advantage of the […]

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Uncategorized Published - 13 March, 2024    By - Dr Clemens
Impaired Lactate Release in Dorsal CA1 Astrocytes Contributed to Nociceptive Sensitization and Comorbid Memory Deficits in Rodents

Authors: Shuang Han, B.S. et al  Anesthesiology March 2024, Vol. 140, 538–557. Background Memory deficits are a common comorbid disorder in patients suffering from neuropathic pain. The mechanisms underlying the comorbidities remain elusive. The hypothesis of this study was that impaired lactate release from dysfunctional astrocytes in dorsal hippocampal CA1 contributed to memory deficits. Methods A […]

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Uncategorized Published - 13 March, 2024    By - Dr Clemens
Isoflurane Inhibits the Na+/K+-ATPase: Comment

Author: Mats Enlund, M.D., Ph.D. Anesthesiology March 2024, Vol. 140, 634–635. To the Editor: I was deeply impressed by the recently published work “Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na+/K+-ATPase Impairment in the Rat Brain” by Reiffurth et al.  A long time ago, I was introduced by chance to Professor Gunnar […]

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