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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Suzetrigine for the Treatment of Acute Pain: Comment

Authors: Siddiqui A et al. Journal: Anesthesiology, February 2026 (accepted October 17, 2025). DOI: 10.1097/ALN.0000000000005828 SummaryThis letter to the editor provides a critical appraisal of recently published phase 3 trials evaluating suzetrigine for the treatment of moderate-to-severe acute pain. The authors focus on the interpretation of efficacy metrics and whether the reported outcomes meet accepted […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
Intraoperative Cardiac Events in Pediatric Patients with Congenital Heart Disease Undergoing Noncardiac Procedures

Authors: Nasr VG et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005783 SummaryThis large multicenter registry study evaluated the incidence and risk factors for intraoperative cardiac events in pediatric patients with congenital heart disease (CHD) undergoing noncardiac procedures. Unlike prior studies limited to mortality outcomes or single-center experiences, this analysis provides granular, contemporary data on […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
Respiratory and antinociceptive effects of NOP-MOP agonist cebranopadol versus full opioid receptor agonist oxycodone

Authors: Jansen S et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005894 SummaryThis randomized, double-blind, placebo-controlled crossover study compared the respiratory and analgesic effects of cebranopadol—a dual nociceptin (NOP) and mu-opioid (MOP) receptor agonist—with those of the full MOP agonist oxycodone in healthy volunteers. Given ongoing concerns about opioid-induced respiratory depression, the investigators sought to […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
The 5 biggest anesthesia disruptions coming in 2026

Author: Sophie Eydis Becker’s ASC Review Anesthesiology is heading into a pivotal year, as workforce volatility, reimbursement pressure and policy shifts collide with rising surgical demand and expanding outpatient care. After a period of partial stabilization, leaders say the structural forces reshaping how anesthesia is staffed, paid and deployed are intensifying, with direct implications for hospitals, […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
General Anesthesia and Systemic Hyperosmolality Modulate Lumbar Intrathecal Drug Distribution in Female Rats

Authors: Persson NDA et al. Journal: Anesthesiology, December 12, 2025. DOI: 10.1097/ALN.0000000000005794 SummaryThis preclinical imaging study examined how general anesthetic technique and systemic hyperosmolality influence the distribution of intrathecally administered drugs delivered at the lumbar level. Because lumbar intrathecal drug delivery often fails to achieve therapeutic intracranial concentrations, the investigators explored whether anesthetic choice and […]

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