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Uncategorized Published - 22 April, 2024    By - Dr Clemens
Liposomal Bupivacaine, Scientific Evidence, and the Clinician’s Conundrum

Author: James P. Rathmell, M.D. Anesthesiology May 2024, Vol. 140, 865–867. “Understanding that the scientific process is messy and imperfect, let’s heed the courts’ direction by continuing open and respectful debate in the published literature […].” It is New Year’s Day 2024, and I am in my office in Boston on the first day in my […]

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Uncategorized Published - 19 April, 2024    By - Dr Clemens
Meta-analyses of Randomized Clinical Trials in Postsurgical Pain: Verify before Trusting

Authors: Jonathan Slonin, M.D., M.B.A. et al  Anesthesiology May 2024, Vol. 140, 874–876. “[M]eta-analyses play a primary role in evidence-based medicine, yet several pervasive challenges can undermine their interpretability […].” Systematic reviews and meta-analyses of randomized clinical trials are widely considered the highest level of clinical evidence.  Because of their substantial influence on medical practice, meta-analyses […]

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Uncategorized Published - 19 April, 2024    By - Dr Clemens
Science, Medicine, and the Anesthesiologist

Anesthesiology May 2024, Vol. 140, A13–A15. A placebo-controlled trial of percutaneous coronary intervention for stable angina. N Engl J Med 2023; 389:2319–30. PMID: 38015442. Article Selection: BobbieJean Sweitzer, M.D. Image: Adobe Stock. The efficacy of percutaneous coronary interventions (PCIs) on symptom relief in patients with stable angina on little or no antianginal medications is uncertain. This […]

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Uncategorized Published - 19 April, 2024    By - Dr Clemens
Postpartum Guillain-Barré Syndrome

Authors: Chen M et al Cureus 16(2): e55207. doi:10.7759/cureus.55207 Abstract Guillain-Barré syndrome (GBS) is a rare acute-onset neurological disease with significant morbidity and mortality. The risk of GBS increases after delivery. Labor and delivery presents many possible risk factors for GBS. However, risk factors and prognosis of postpartum GBS remain unclear due to its low incidence. Here, […]

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Uncategorized Published - 19 April, 2024    By - Dr Clemens
What Language Is the Brain Speaking?

Authors: Jamie W. Sleigh, M.D.; Logan Voss, Ph.D. Anesthesiology May 2024, Vol. 140, 881–883. “[T]he optimal monitor of consciousness for anesthesia will be the one that is quantifying disturbances at whichever syntactic level is most closely linked to the actual generation of the brain semantics (i.e., the ‘mind’).” The prevailing paradigm of brain function assumes that […]

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