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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Suzetrigine for the Treatment of Acute Pain: Reply

Authors: Bertoch T et al. Journal: Anesthesiology, December 11, 2025. DOI: 10.1097/ALN.0000000000005825 SummaryThis reply addresses multiple commentaries regarding the clinical meaningfulness, demographic consistency, and comparative efficacy of suzetrigine for moderate-to-severe acute pain. The authors clarify points raised about subgroup effects, outcome interpretation, and comparison with established opioid analgesics. The authors emphasize that phase 3 randomized […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Relationship between Ventilation/Perfusion Ratio Mismatch and Capnogram Phase III Slope in Acute Bronchoconstriction and Its Modulation by Salbutamol Assessed by Synchrotron Imaging in Rabbit Lung

Authors: Bayat S et al. Journal: Anesthesiology, December 12, 2025. DOI: 10.1097/ALN.0000000000005807 SummaryThis experimental physiologic study examined whether the slope of phase III of the volumetric capnogram (SIII) truly reflects ventilation–perfusion (V/Q) mismatch during acute bronchoconstriction and how this relationship is altered by bronchodilator therapy. Using a rabbit model and high-resolution synchrotron radiation imaging, the […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
BEST Independent CRNA Opportunity – Savannah, TN just increased salary $15,000

Hardin Medical Center (122 beds) is offering a rare CRNA-only practice where you can enjoy full autonomy and an exceptional lifestyle. • Schedule: 2 weeks on / 1 week off (17 weeks off each year)• Model: Independent CRNA practice – no anesthesiologist supervision• Case Mix: General surgery, orthopedics, endoscopy, OB/GYN (including epidurals & C-sections)• No […]

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Anesthesiology Published - 8 January, 2026    By - Dr Clemens
Suzetrigine for the Treatment of Acute Pain: Comment

Authors: Siddiqui A et al. Journal: Anesthesiology, February 2026 (accepted October 17, 2025). DOI: 10.1097/ALN.0000000000005828 SummaryThis letter to the editor provides a critical appraisal of recently published phase 3 trials evaluating suzetrigine for the treatment of moderate-to-severe acute pain. The authors focus on the interpretation of efficacy metrics and whether the reported outcomes meet accepted […]

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Anesthesiology Published - 7 January, 2026    By - Dr Clemens
Intraoperative Cardiac Events in Pediatric Patients with Congenital Heart Disease Undergoing Noncardiac Procedures

Authors: Nasr VG et al. Journal: Anesthesiology, December 9, 2025. DOI: 10.1097/ALN.0000000000005783 SummaryThis large multicenter registry study evaluated the incidence and risk factors for intraoperative cardiac events in pediatric patients with congenital heart disease (CHD) undergoing noncardiac procedures. Unlike prior studies limited to mortality outcomes or single-center experiences, this analysis provides granular, contemporary data on […]

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