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Uncategorized Published - 7 May, 2024    By - Dr Clemens
Influence of Intravenous S-Ketamine on the Pharmacokinetics of Oral Morphine in Healthy Volunteers

AUTHORS: Lohela, Terhi J. MD, PhD et al   Anesthesia & Analgesia 138(3):p 598-606, March 2024. BACKGROUND: Subanesthetic ketamine may reduce perioperative consumption of opioids. We studied whether intravenous S-ketamine alters the pharmacokinetics of oral morphine in healthy volunteers. METHODS: In this paired, randomized, double-blind, crossover trial, 12 participants under a 2-hour intravenous S-ketamine (0.57 mg/kg/h) […]

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Uncategorized Published - 7 May, 2024    By - Dr Clemens
Associations Between Fresh Gas Flow and Duration of Anesthetic on the Maximum Potential Benefit of Anesthetic Gas Capture in Operating Rooms and in Postanesthesia Care Units to Capture Waste Anesthetic Gas

AUTHORS: Dexter, Franklin MD, PhD, FASA*; Epstein, Richard H. MD, FASA† Anesthesia & Analgesia 137(5):p 1104-1109, November 2023.  BACKGROUND:  Sevoflurane and desflurane are halogenated hydrocarbons with global warming potential. We examined the maximum potential benefit assuming 100% efficiency of waste gas capture technology used in operating rooms and recovery locations. METHODS: We performed computer simulations […]

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Uncategorized Published - 6 May, 2024    By - Dr Clemens
Administration of Milrinone Following Tetralogy of Fallot Repair Increases Postoperative Volume Administration Without Improving Cardiac Output

AUTHORS: Saengsin, Kwannapas MD et al Anesthesia & Analgesia 137(5):p 1056-1065, November 2023. BACKGROUND: Phosphodiesterase inhibitors are known to relieve symptoms in the setting of heart failure, although their effects in restrictive ventricular physiology have been poorly characterized. We explored the association between the use of milrinone and volume administration during the first 72 hours following […]

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Uncategorized Published - 6 May, 2024    By - Dr Clemens
Arterial Hyperoxemia During Cardiopulmonary Bypass Was Not Associated With Worse Postoperative Pulmonary Function

AUITHORS: Kelava, Marta MD, MS et al  Anesthesia & Analgesia 138(5):p 1003-1010, May 2024 BACKGROUND: Arterial hyperoxemia may cause end-organ damage secondary to the increased formation of free oxygen radicals. The clinical evidence on postoperative lung toxicity from arterial hyperoxemia during cardiopulmonary bypass (CPB) is scarce, and the effect of arterial partial pressure of oxygen (Pao2) […]

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Uncategorized Published - 6 May, 2024    By - Dr Clemens
Postanesthesia Care Unit Recovery Time According to Volatile Anesthetic Used in Clinical Practice

AUTHORS: Sprung, Juraj MD, PhD et al  Anesthesia & Analgesia 137(5):p 1066-1074, November 2023. BACKGROUND: Whether volatile anesthetic solubility affects postanesthesia recovery time in clinical practice is unclear. We investigated the association among 3 volatile agents and 2 clinically relevant outcomes—postanesthesia care unit (PACU) recovery time (time from PACU admission to fulfillment of discharge criteria) and […]

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