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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Dexmedetomidine Inhibits Paraventricular Corticotropin-releasing Hormone Neurons that Attenuate Acute Stress-induced Anxiety-like Behavior in Mice

Authors: Gaolin Qiu, M.D. et al  Anesthesiology June 2024, Vol. 140, 1134–1152. Background Dexmedetomidine has repeatedly shown to improve anxiety, but the precise neural mechanisms underlying this effect remain incompletely understood. This study aims to explore the role of corticotropin-releasing hormone–producing hypothalamic paraventricular nucleus (CRHPVN) neurons in mediating the anxiolytic effects of dexmedetomidine. Methods A social […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Association between Colonoscopy Sedation Type and Polyp Detection

Authors: Aurora N. Quaye, M.D. et al  Anesthesiology June 2024, Vol. 140, 1088–1097. Background Colorectal cancer is a leading cause of cancer-related death. Adenomas and serrated polyps are precursors of colorectal cancer, with serrated polyps being more difficult to detect during colonoscopy. The relationship between propofol use and polyp detection remains unclear. The authors investigated the […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
Tethered Spinal Cord Syndrome Discovered during Ultrasound-guided Caudal Block

Authors: Ramón Eizaga Rebollar, M.D. et al  Anesthesiology June 2024, Vol. 140, 1203–1204. Figure 1, B and C correspond to a healthy 2-yr-old boy who underwent hypospadias repair during general anesthesia combined with ultrasound-guided continuous caudal block. Mid-sagittal plane lumbar ultrasound (Sonosite SII, FUJIFILM Sonosite, Inc., USA) showed the dural sac end at S4 vertebral level, significantly lower for […]

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Uncategorized Published - 28 May, 2024    By - Dr Clemens
μ-Opioid Receptor Activation at the Dorsal Reticular Nucleus Shifts Diffuse Noxious Inhibitory Controls to Hyperalgesia in Chronic Joint Pain in Male Rats

Authors: Raquel Pereira-Silva, Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1176–1191. Background The dorsal reticular nucleus is a pain facilitatory area involved in diffuse noxious inhibitory control (DNIC) through opioidergic mechanisms that are poorly understood. The hypothesis was that signaling of μ-opioid receptors is altered in this area with prolonged chronic inflammatory pain and that […]

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Uncategorized Published - 27 May, 2024    By - Dr Clemens
Happy Memorial Day

Honoring the Heroes: A Reflection on Memorial Day I want to thank our readers and wish them a fun and safe Memorial Day. Please remember that today is a day of reflection, remembrance, and gratitude for those who laid down their lives in service to the nation. Memorial Day serves as a powerful reminder of […]

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