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Uncategorized Published - 20 June, 2024    By - Dr Clemens
Antithrombin Levels and Heparin Responsiveness during Venoarterial Extracorporeal Membrane Oxygenation

Authors: Alexandre Mansour, M.D., Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1153–1164. Background Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent on extracorporeal membrane oxygenation; however, its association with acquired antithrombin deficiency is poorly understood. The objective […]

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Uncategorized Published - 20 June, 2024    By - Dr Clemens
Predicting Fluid Responsiveness Using Carotid Ultrasound in Mechanically Ventilated Patients

AUTHORS: Lipszyc, Adam C. MD et al Anesthesia & Analgesia 138(6):p 1174-1186, June 2024. BACKGROUND: A noninvasive and accurate method of determining fluid responsiveness in ventilated patients would help to mitigate unnecessary fluid administration. Although carotid ultrasound has been previously studied for this purpose, several studies have recently been published. We performed an updated systematic review […]

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Uncategorized Published - 20 June, 2024    By - Dr Clemens
Preoperative Transfusion and Sickle Cell Disease in the Pediatric Patient

Authors: Rahul Baijal, MD; Priti Dalal, MD; Megha Kanjia, MD Anesthesia Patient Safety Foundation June 2024 Volume 39, No. 2  SUMMARY:Perioperative complications are more common in patients with SCD compared to the general population with an increased risk of postoperative acute chest syndrome (ACS), infections, vaso-occlusive pain crises, and 30-day mortality. Children with SCD have […]

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Uncategorized Published - 20 June, 2024    By - Dr Clemens
Pulse Oximetric Pulse Rate: What Are We Measuring?

Authors: Michael Vandenheuvel, MD et al  Anesthesia Patient Safety Foundation June 2024 Volume 39, No. 2 DEAR RAPID RESPONSE: Since the 1970s, the pulse oximeter (PO) has enabled noninvasive continuous assessment of arterial blood oxygenation as well as pulse rate. The pulse estimate is derived from the plethysmographic waveform and serves as a proxy for […]

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Uncategorized Published - 20 June, 2024    By - Dr Clemens
μ-Opioid Receptor Activation at the Dorsal Reticular Nucleus Shifts Diffuse Noxious Inhibitory Controls to Hyperalgesia in Chronic Joint Pain in Male Rats

Authors: Raquel Pereira-Silva, Ph.D. et al  Anesthesiology June 2024, Vol. 140, 1176–1191. Background The dorsal reticular nucleus is a pain facilitatory area involved in diffuse noxious inhibitory control (DNIC) through opioidergic mechanisms that are poorly understood. The hypothesis was that signaling of μ-opioid receptors is altered in this area with prolonged chronic inflammatory pain and that […]

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