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Uncategorized Published - 7 August, 2024    By - Dr Clemens
Electroencephalographic Indices for Clinical Endpoints during Propofol Anesthesia in Infants: An Early-phase Propofol Biomarker-finding Study

Authors: Ian Yuan, M.D., M.Eng. et al  Anesthesiology August 2024, Vol. 141, 353–364. Background Unlike expired sevoflurane concentration, propofol lacks a biomarker for its brain effect site concentration, leading to dosing imprecision particularly in infants. Electroencephalography monitoring can serve as a biomarker for propofol effect site concentration, yet proprietary electroencephalography indices are not validated in infants. […]

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Uncategorized Published - 7 August, 2024    By - Dr Clemens
Electrical Impedance Tomography for Assessing the Impact of Inhaled Nitric Oxide on Pulmonary Artery Pressure

Authors: Gamonmas Ekkapat, M.D. et al  Anesthesiology August 2024, Vol. 141, 377–378. A 43-yr-old woman experienced acute respiratory failure with right ventricular dysfunction following a complex left pneumonectomy (fig. 1A) with cardiopulmonary bypass. She was intubated and mechanically ventilated. Fig. 1. (A) Chest x-ray showing patchy opacities at the right middle and lower lung zones along […]

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Uncategorized Published - 7 August, 2024    By - Dr Clemens
A Practical Dosing Algorithm for Deep Neuromuscular Blockade during Total Intravenous Anesthesia: ROCURITHM

Authors: Kim I. Albers-Warlé, M.D et al  Anesthesiology August 2024, Vol. 141, 365–374. Background The number of trials investigating the effects of deep neuromuscular blockade (NMB) on surgical conditions and patient outcomes is steadily increasing. Consensus on which surgical procedures benefit from deep NMB (a posttetanic count [PTC] of 1 to 2) and how to implement […]

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Uncategorized Published - 7 August, 2024    By - Dr Clemens
Science, Medicine, and the Anesthesiologist

Anesthesiology August 2024, Vol. 141, A13–A15. Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. Nat Med 2024; 30:810–7. PMID: 38454125. Acute kidney injury after hypoperfusion is common and it has a higher occurrence in older patients but has not previously been clearly associated with genetic risk factors. Clonal hematopoiesis of indeterminate potential is […]

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Uncategorized Published - 7 August, 2024    By - Dr Clemens
Are Genome-wide Association Studies Worth the Trouble?

Authors: Jamie W. Sleigh, M.D.; Philip G. Morgan, M.D. Anesthesiology August 2024, Vol. 141, 214–216. “[T]he confusing results of GWAS do suggest that the mechanisms of how the genome manifests expression in a living human may be more subtle and complex than the traditionally taught paradigm of DNA–mRNA–tRNA–protein.” Practicing clinicians spend their days managing the variability in […]

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