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Uncategorized Published - 6 November, 2024    By - Dr Clemens
Neuropeptide Y Y2 Receptors in Sensory Neurons Tonically Suppress Nociception and Itch but Facilitate Postsurgical and Neuropathic Pain Hypersensitivity

Authors: Paramita Basu, Ph.D. et al  Anesthesiology November 2024, Vol. 141, 946–968. Background Neuropeptide Y (NPY) Y2 receptor (Y2) antagonist BIIE0246 can both inhibit and facilitate nociception. The authors hypothesized that Y2 function depends on inflammation or nerve injury status. Methods The authors implemented a battery of behavioral tests in mice of both sexes that received […]

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Uncategorized Published - 6 November, 2024    By - Dr Clemens
Calcium-activated Potassium Channels as Amplifiers of TRPV4-mediated Pulmonary Edema Formation in Male Mice

Authors: Mei Li, M.D. et al  Anesthesiology November 2024, Vol. 141, 913–928. Background As a mechanosensitive cation channel and key regulator of vascular barrier function, endothelial transient receptor potential vanilloid type 4 (TRPV4) contributes critically to ventilator-induced lung injury and edema formation. Ca2+ influx via TRPV4 can activate Ca2+-activated potassium (KCa) channels, categorized into small (SK1-3), intermediate (IK1), and […]

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Uncategorized Published - 5 November, 2024    By - Dr Clemens
Intraoperative Mechanical Power: Reply

Authors: Cédric Cirenei, M.D. et al  Anesthesiology November 2024, Vol. 141, 1019–1020. In Reply: We thank Deng et al. for their interest in our recently published article, “Intraoperative Mechanical Power and Postoperative Pulmonary Complications in Noncardiothoracic Elective Surgery Patients: A 10-Year Retrospective Cohort Study.”  Indeed, the fraction of inspired oxygen (Fio2) was recorded but not extracted nor […]

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Uncategorized Published - 5 November, 2024    By - Dr Clemens
A Comparison of the Effects of Different Positive End-Expiratory Pressure Levels on Respiratory Parameters During Prone Positioning Under General Anaesthesia

Authors:  Shanmugam Y, Venkatraman R, KY A Cureus 16(9: e68693. doi:10.7759/cureus.68693 Background and objective In general anesthesia, for certain surgical procedures in the prone position, patients often face increased airway pressures, reduced pulmonary and thoracic compliance, and restricted chest expansion, all of which can affect venous return and cardiac output, impacting overall hemodynamic stability. Positive […]

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Uncategorized Published - 5 November, 2024    By - Dr Clemens
Intraoperative Mechanical Power: Comment

Authors: Xiao Deng, M.M.; Hao Li, M.D.; Xuemei Lin, M.D. Anesthesiology November 2024, Vol. 141, 1019. To the Editor: We read with great interest the article by Elefterion et al.  titled “Intraoperative Mechanical Power and Postoperative Pulmonary Complications in Noncardiothoracic Elective Surgery Patients: A 10-Year Retrospective Cohort Study” published in the March 2024 issue of Anesthesiology. The study found that lower […]

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