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Neural circuit basis of placebo pain relief. Nature 2024; 632:1092–100. PMID: 39048016. Author: Steven P. Cohen, M.D. Anesthesiology December 2024, Vol. 141, A13–A15. The placebo effect exerts an enormous role for pain, being greater than the intrinsic effects of most therapies. Yet, the neural basis remains unclear. A 7-day placebo analgesia conditioning (PAC) assay was developed, […]
Read MoreAuthors: James M Hitt, M.D., Ph.D. et al Anesthesiology November 2024. Background Prescription rates for buprenorphine in opioid use disorder are increasing, and recent guidelines recommend its continuation during and after surgery; however, evidence from clinical outcome studies is limited. We tested the hypotheses that 1) perioperative continuation of buprenorphine does not result in higher […]
Read MoreAuthors: Annie Xin, PhD et al Anesthesiology November 2024. Background The GAS trial demonstrated evidence that most neurodevelopmental outcomes at 2 years and 5 years of age in infants who received a single general anaesthetic (GA) for elective inguinal herniorrhaphy were clinically equivalent when compared to infants who did not receive GA. More than 20% […]
Read MoreAuthor: Nathan L. Pace, M.D., M.Stat. Anesthesiology November 2024. To the Editor: I write to offer a comment and a suggestion on the systematic review and meta-analysis by Hussain et al. of local anesthetics used for fascial plane block. This report compared analgesia between liposomal bupivacaine and plain bupivacaine, the primary outcome being rest pain scores over […]
Read MoreAuthors: Nasir Hussain, M.D., M.Sc.; Faraj W. Abdallah, M.D., M.Sc. Anesthesiology November 2024. In Reply: We thank Dr. Pace for selecting our publication highlighting the lack of difference between liposomal and plain bupivacaine, and presenting alternative findings that are based on the differences between the frequentist and Bayesian approaches for meta-analyses. We present in this reply a […]
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