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Uncategorized Published - 4 December, 2024    By - Dr Clemens
Remimazolam and Ciprofol: More Research Is Needed but Ask the Right Questions and Perhaps Aim Higher

Authors: J. Robert Sneyd, M.D., Ph.D.; Brian J. Anderson, M.B., Ch.B., Ph.D. Anesthesiology December 2024, Vol. 141, 1034–1038. City dwellers of a certain age will recall lengthy waits for a bus followed eventually by the arrival of three on the same route driving nose-to-tail. So it is with intravenous hypnotics. Since the discovery of propofol, it has […]

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Uncategorized Published - 4 December, 2024    By - Dr Clemens
Preoperative Strategies for Patients on Glucagon-like Peptide-1 Receptor Agonists Navigating Current Controversies and Future Directions

Author: Girish P. Joshi, M.B.B.S., M.D. Anesthesiology December 2024, Vol. 141, 1031–1033. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as valuable therapeutic options for managing type 2 diabetes mellitus because they allow glycemic control without increasing the potential for hypoglycemia.  Also, they provide significant cardiovascular and renal benefits as well as lead to weight loss.  In addition to […]

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Uncategorized Published - 4 December, 2024    By - Dr Clemens
Science, Medicine, and the Anesthesiologist

Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation-contraction coupling in ventricular myocytes. Proc Natl Acad Sci USA 2024; 121:e2318535121. PMID: 38865270. Author: Michael Zaugg, M.D., M.B.A. The human cardiac muscle requires a vast amount of adenosine triphosphate (ATP) for the approximately 100,000 beats/day. This study investigated the impact of excitation-contraction coupling on the […]

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Uncategorized Published - 3 December, 2024    By - Dr Clemens
Effects of Serratus Anterior Plane Block on Early Recovery from Thoracoscopic Lung Resection

Authors: Jacob C. Jackson, M.D. et al  Anesthesiology December 2024, Vol. 141, 1065–1074. Background The efficacy of serratus anterior plane block for treatment of pain after minimally invasive thoracic surgery remains unclear. This trial assesses the impact of serratus anterior plane block on postoperative opioid consumption and on measures of early recovery after thoracoscopic lung resection. […]

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Uncategorized Published - 3 December, 2024    By - Dr Clemens
Short-term Outcomes in Infants after General Anesthesia with Low-dose Sevoflurane/Dexmedetomidine/Remifentanil versus Standard-dose Sevoflurane (the TREX Trial)

Authors: Rita Saynhalath, M.D. et al  Anesthesiology December 2024, Vol. 141, 1075–1085. Background The Trial Remifentanil DEXmedetomidine (TREX) trial aimed to determine whether, in children less than 2 yr old, low-dose sevoflurane/dexmedetomidine/remifentanil anesthesia is superior to standard-dose sevoflurane anesthesia in terms of global cognitive function at 3 yr of age. The aim of the current secondary […]

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