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Uncategorized Published - 1 April, 2025    By - Dr Clemens
Influence of Repeated Exposure to Neonatal Isoflurane on Sleep Architecture and Neuronal Delta and Theta Oscillations in Adolescent Rats

AUTHORS: Armijo, Arthur J. DO, MS, MPH et al Anesthesia & Analgesia March 06, 2025. BACKGROUND: Normal sleep architecture is important for brain development, and we previously demonstrated that a single exposure to isoflurane during the neonatal period did not induce changes in the sleep architecture and only minimally altered neuronal beta oscillations in adolescent […]

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Uncategorized Published - 1 April, 2025    By - Dr Clemens
The Probability Distribution of Times to Awakening From Sevoflurane Anesthesia, Among a Homogeneous Group of Cases With the Same Age-Adjusted Minimum Alveolar Concentration Fraction

AUTHORS: Dexter, Franklin MD, PhD et al Anesthesia & Analgesia February 28, 2025. BACKGROUND: Human studies of awakening from general anesthesia inform understanding of neural mechanisms underlying recovery of consciousness. Probability distributions of times for emergence from anesthesia provide mechanistic information on whether putative biological models are generalizable. Previously reported distributions involved nonhomogenous groups, unsuitable […]

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Uncategorized Published - 31 March, 2025    By - Dr Clemens
Inspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery

AUTHORS: Douville, Nicholas J. MD, PhD et al Anesthesia & Analgesia March 10, 2025. BACKGROUND: A recent multicenter study suggested that the duration of single-lung ventilation, and not the intensity of the hyperoxia (ie, inspired oxygen fraction) during this period, contributes to the development of postoperative pulmonary complications. However, lung reinflation, at the cessation of […]

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Uncategorized Published - 31 March, 2025    By - Dr Clemens
Effects of Perioperative Exposure on the Microbiome and Outcomes From an Immune Challenge in C57Bl/6 Adult Mice

AUTHORS: Serbanescu, Mara MD et al Anesthesia & Analgesia (March 10, 2025. BACKGROUND: Previous work suggests that the gut microbiome can be disrupted by antibiotics, anesthetics, opiates, supplemental oxygen, or nutritional deprivation—all of which are common and potentially modifiable perioperative interventions that nearly all patients are exposed to in the setting of surgery. Gut microbial dysbiosis […]

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Uncategorized Published - 31 March, 2025    By - Dr Clemens
In vitro performance of a charcoal capturing device with desflurane

Authors: Hoffmann, Maurits M.D. et al  Anesthesiology March 12, 2025. Background: The use of capturing devices may become required for the continued use desflurane. We tested the percentage of desflurane captured by a charcoal filter (CONTRAfluran)-workstation (Aisys) combination in vitro. Methods: Desflurane in O2/air was administered via an Aisys workstation into a 2 L test […]

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