Published in Anesth Analg. 2014 May;118(5):946-55 Authors: Le Guen M et al., BACKGROUND: The α2-adrenergic agonist dexmedetomidine is a sedative and can be used as an adjunct to anesthetics. Our primary goal was thus to determine the extent to which dexmedetomidine reduces the requirement for propofol and remifentanil. METHODS: This double-blinded, randomized study […]
Read MorePublished in Allergol Int. 2014 Apr Authors: Saito M et al. Background: There are problems in diagnosis of allergy to amide-type local anesthetic agents (ALAs), because definitive diagnosis is not obtained by in vivo tests, which are used for the diagnosis. Consequently, patients may be exposed to risk. There are few diagnoses based […]
Read MoreAuthors: Abroug F and Krishnan JA., Am J Respir Crit Care Med 2014 May 1; 189:1014 Patients with chronic obstructive pulmonary disease exacerbations who require intensive care admission do better with low-dose steroids. A 2010 observational study suggested that relatively low-dose oral corticosteroids were as good as — or better than — high-dose parenteral steroids […]
Read MoreAuthors: Donnino MW et al., Crit Care Med 2014 Apr 25; Lower lactate levels and more rapid lactate clearance were associated with improved survival and good neurologic outcomes. Although guidelines recommend serial lactate measurements to assess perfusion in critically ill patients, data to support this approach are derived mainly from burn, trauma, and septic patients […]
Read MoreAuthors: Clarke H et al., BMJ 2014 Feb 11; 348:g1251 A small but substantial percentage of opiate-naïve patients were still taking pain medications 90 days after major surgery. Annually, more than 200 million patients undergo major surgery worldwide. Many patients require treatment with opiates for moderate-to-severe postoperative pain; most quickly transition off of pain medications. […]
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