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There is growing anticipation in the headache community about the arrival of a variety of monoclonal antibodies that target the calcitonin gene-related peptide (CGRP) pathway to prevent migraine headaches. CGRP is involved in the pathophysiology of migraine. Levels of CGRP are elevated during migraine attacks and decrease with resolution of the attacks. Several pharmaceutical companies […]
Read MoreA total knee replacement is a very common operation and more than 700,000 of them are performed each year in the United States. With a mean cost of about $16,000 each, in 2011 we spent over eleven billion dollars paying for knee replacements. Projections are that, by 2030, we’ll be doing 3.5 million per year. […]
Read MorePublished in Int J Urol. 2014 Jun 26. Authors: Lunacek A et al OBJECTIVE: To assess the most effective local analgesia during transrectal ultrasound-guided prostate biopsy. METHODS: A total of 123 consecutive patients undergoing transrectal ultrasound-guided prostate biopsy for elevated prostate-specific antigen levels and/or a suspicious digital rectal examination were randomized to three groups. Patients […]
Read MorePublished in Int J Pediatr Otorhinolaryngol. 2014 Jul;78(7):1090-4 Authors: Dewhirst E et al PURPOSE: Despite the brevity of the procedure, bilateral myringotomy and tympanostomy tube placement (BMT) can result in significant postoperative pain and discomfort. As the procedure is frequently performed without intravenous access, non-parenteral routes of administration are frequently used for analgesia. The current […]
Read MoreI am often asked for a simple, effective, no-nonsense approach to goal setting that can be used by anyone, anywhere, anytime. What follows is what I affectionately call the Six Step Makeover. It’s a simple process that’s easy to learn, easy to apply, and easy to get results from. Follow it to the letter and […]
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