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Uncategorized Published - 14 January, 2015    By - Dr Clemens
Role of Spinal CXCL1 (GROα) in Opioid Tolerance: A Human-to-rodent Translational Study

Published in Journal of the American Society of Anesthesiologists 11/2014. Authors: Chih-Peng Lin, M.D. et al Background: The pivotal role of glial activation and up-regulated inflammatory mediators in the opioid tolerance has been confirmed in rodents but not yet in humans. Here, the authors investigated the intraspinal cytokine and chemokine profiles of opioid-tolerant cancer patients; […]

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Uncategorized Published - 13 January, 2015    By - Dr Clemens
Intubation and Obesity

Published in Br J Anaesth 2014 Nov 27 Authors: De Jong A et al. Obesity and critical illness are dangerous in combination. Obesity affects all components of airway management, including oxygenation, bag-valve-mask ventilation, and choice of pharmacologic agents, intubation surgical airway, and rescue devices. In a prospective, multicenter, observational study, researchers in France assessed the […]

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Uncategorized Published - 13 January, 2015    By - Dr Clemens
Healthcare spending may reach $10K per person this year

The year 2015 may be the time when healthcare spending in the United States reaches a specific milestone: $10,000 per person. The National Healthcare Expenditure may reach $3.2 trillion this year, according to Forbes magazine. Based on a population of 320 million Americans, that would mean spending $10,000 per person. That number may be reached […]

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Uncategorized Published - 13 January, 2015    By - Dr Clemens
Invasive Treatments for Complex Regional Pain Syndrome in Children and Adolescents: A Scoping Review

Published in Journal of the American Society of Anesthesiologists 12 2014. Authors: Boris Zernikow, M.D., Ph.D et al This review aimed to synthesize the current evidence on the effectiveness of invasive treatments for complex regional pain syndrome in children and adolescents. Studies on children and adolescents with complex regional pain syndrome that evaluated the effects […]

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Uncategorized Published - 13 January, 2015    By - Dr Clemens
Up-regulation of MicroRNA-21 Mediates Isoflurane-induced Protection of Cardiomyocytes

Published in Journal of the American Society of Anesthesiologists in 2/2015. Authors: Jessica M. Olson, M.S. et al Background: Anesthetic cardioprotection reduces myocardial infarct size after ischemia–reperfusion injury. Currently, the role of microRNA in this process remains unknown. MicroRNAs are short, noncoding nucleotide sequences that negatively regulate gene expression through degradation or suppression of messenger […]

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