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Uncategorized Published - 6 March, 2015    By - Dr Clemens
Pharmacokinetics of ε-Aminocaproic Acid in Neonates Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Published in Anesthesiology on 02 2015. Authors: Michael P. Eaton, M.D. et al Background: Antifibrinolytic medications such as ε-aminocaproic acid (EACA) are used in pediatric heart surgery to decrease surgical bleeding and transfusion. Dosing schemes for neonates are often based on adult regimens, or are simply empiric, in part due to the lack of neonatal pharmacokinetic information. […]

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Uncategorized Published - 6 March, 2015    By - Dr Clemens
Prediction of Movement to Surgical Stimulation by the Pupillary Dilatation Reflex Amplitude Evoked by a Standardized Noxious Test

Published in Anesthesiology on 03 2015 Authors: Jean Guglielminotti, M.D., Ph.D. Background: Individual assessment of the amplitude of a physiologic reflex evoked by a standardized noxious test (SNT) before surgical stimulation has been suggested to predict movement upon the forthcoming surgical stimulation. This study aimed to compare the ability of pupillary dilatation reflex amplitude (PDRA) evoked by […]

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Uncategorized Published - 6 March, 2015    By - Dr Clemens
Monitoring Obstetric Anesthesia Safety across Hospitals through Multilevel Modeling

Published in Anesthesiology on 03 2015 Authors: Jean Guglielminotti, M.D., Ph.D. Background: The rate of anesthesia-related adverse events (ARAEs) is recommended for monitoring patient safety across hospitals. To ensure comparability, it is adjusted for patients’ characteristics with logistic models (i.e., risk adjustment). The rate adjusted for patient-level characteristics and hospital affiliation through multilevel modeling is suggested as […]

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Uncategorized Published - 6 March, 2015    By - Dr Clemens
Corneal Abrasion in Hysterectomy and Prostatectomy: Role of Laparoscopic and Robotic Assistance

Published in Anesthesiology in 03 2015. Authors: Ajay Sampat, M.D. et al Background: Radical prostatectomy (RP) is most commonly performed laparoscopically with a robot (robotic-assisted laparoscopic radical prostatectomy, R/PROST). Hysterectomy, which may be open hysterectomy (O/HYST) or laparoscopic hysterectomy (L/HYST), has been increasingly frequently done via robot (R/HYST). Small case series suggest increased corneal abrasions (CAs) with less invasive […]

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Uncategorized Published - 5 March, 2015    By - Dr Clemens
Syntaxin1A-mediated Resistance and Hypersensitivity to Isoflurane in Drosophila melanogaster

Published in Anesthesiology in 03 2015 Authors: Oressia H. Zalucki, B.Sc., B.A. et al Background: Recent evidence suggests that general anesthetics activate endogenous sleep pathways, yet this mechanism cannot explain the entirety of general anesthesia. General anesthetics could disrupt synaptic release processes, as previous work inCaenorhabditis elegans and in vitro cell preparations suggested a role for the soluble NSF attachment […]

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