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Published in Anesthesia & Analgesia: April 2015 Authors: Puri, Goverdhan D. MD, PhD et al BACKGROUND: Closed-loop systems for anesthesia delivery have been shown to outperform traditional manual control in different clinical settings. The present trial was aimed at evaluating the feasibility and efficacy of Bispectral Index (BISTM)-guided closed-loop anesthesia delivery system (CLADS) in comparison […]
Read MoreAnesthesia & Analgesia: April 2015 Issue 1 page 149-158 Authors: Heesen, Michael MD et al BACKGROUND: Patient-controlled epidural analgesia (PCEA) has gained popularity, but it is still unclear whether adding a background infusion confers any benefit. METHODS: A systematic literature search in PubMed, Embase, CINAHL, LILACS, CENTRAL, Clinicaltrials.gov, and ISI WOS was performed to identify […]
Read MorePublished in Anesthesia & Analgesia: May 2015 Authors: Peralta, Feyce MD et al BACKGROUND: Unintentional dural puncture is a known risk after epidural or combined spinal-epidural procedures, occurring in approximately 1% of labor epidural catheters placed in parturients with normal body habitus but may be as high as 4% in morbidly obese parturients. Anecdotal experience […]
Read MorePublished in Anesthesia & Analgesia: April 2015 Authors: Fortier, Louis-Philippe MSc, MD, FRCPC et BACKGROUND: Postoperative residual neuromuscular blockade (NMB), defined as a train-of-four (TOF) ratio of <0.9, is an established risk factor for critical postoperative respiratory events and increased morbidity. At present, little is known about the occurrence of residual NMB in Canada. The […]
Read MoreA fast-acting transdermal gel using a proprietary formulation of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen (Topofen, Achelios Therapeutics) reduced pain severity in patients with severe migraine with and without aura compared with placebo and had few adverse effects. Results from a phase 2a trial of the gel were presented here at the American Academy of […]
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