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Uncategorized Published - 25 April, 2025    By - Dr Clemens
A Randomized Controlled Trial of Adding Deep Parasternal Intercostal Plane Block to Interpectoral-Pectoserratus Plane Block in Breast Cancer Surgery

AUTHORS: Gu, Bin MD et al Anesthesia & Analgesia 140(5):p 1188-1194, May 2025. BACKGROUND: The interpectoral-pectoserratus plane block is expected to anesthetize the lateral breast, but it is unclear whether the deep parasternal intercostal plane block may enhance recovery by providing analgesia to the medial breast. METHODS: Patients undergoing breast cancer surgery were randomly assigned to […]

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Uncategorized Published - 25 April, 2025    By - Dr Clemens
Detection and Evaluation of Procalcitonin Variants As Diagnostic Tools in Systemic Inflammation

AUTHORS: Kintrup, Sebastian MD et al Anesthesia & Analgesia 140(5):p 1073-1082, May 2025. BACKGROUND: Procalcitonin is an indicator of systemic inflammation associated with major surgery or sepsis. Procalcitonin exists in a full-length and truncated variant as a result of dipeptidylpeptidase-4 (DPP4)-cleavage. We recently identified differential biological activity of both variants. Here, we present an immunoassay-based method […]

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Uncategorized Published - 25 April, 2025    By - Dr Clemens
Racial and Ethnic Underserved Populations Prescription Analgesic Use Before and After Lower Extremity Amputation in US Medicare

AUTHORS: Yang, Seonkyeong PhD et al Anesthesia & Analgesia 140(5):p 1205-1215, May 2025. BACKGROUND: Racial disparities exist in access to health care and management of multiple health conditions including chronic pain; however, racial disparities in pre- and postoperative pain management in lower extremity amputation are not well-studied. Our objective was to examine the association between different […]

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Uncategorized Published - 24 April, 2025    By - Dr Clemens
A New Method for Comprehensive Analysis of Benzodiazepine, Opioid, and Propofol Interactions and Dose Selection Rationales in Gastrointestinal Endoscopy Sedation

AUTHORS: Liou, Jing-Yang MD, PhD et al Anesthesia & Analgesia 140(5):p 1168-1177, May 2025. BACKGROUND: The aim of this study was to explore a new method for determining optimal dosing regimens for combinations of propofol, midazolam, and an opioid to achieve rapid on- and off-set of deep sedation. METHODS: We simulated 16 published dosing regimens using […]

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Uncategorized Published - 24 April, 2025    By - Dr Clemens
Assisted Fluid Management and Sublingual Microvascular Flow During High-Risk Abdominal Surgery

AUTHORS: Coeckelenbergh, Sean MD et al Anesthesia & Analgesia 140(5):p 1149-1158, May 2025. BACKGROUND: Implementation of goal-directed fluid therapy (GDFT) protocols remains low. Protocol compliance among anesthesiologists tends to be suboptimal owing to the high workload and the attention required for implementation. The assisted fluid management (AFM) system is a novel decision support tool designed to […]

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