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Authors: Douketis JD et al., N Engl J Med 2015 Aug 27; 373:823 Perioperative “bridging” anticoagulation in warfarin-treated AF patients didn’t prevent thromboembolism but did cause excess major bleeding. In the U.S., many warfarin-treated patients with atrial fibrillation (AF) who undergo elective surgery receive perioperative bridging anticoagulation, despite a paucity of evidence supporting this practice. In this […]
Read MoreAnesthesiology 9 2015, Vol.123, 542-547 Authors: Martin Neukirchen NM et al Background: Impaired cardiac repolarization, indicated by prolonged QT interval, may cause critical ventricular arrhythmias. Many anesthetics increase the QT interval by blockade of rapidly acting potassium rectifier channels. Although xenon does not affect these channels in isolated cardiomyocytes, the authors hypothesized that xenon increases the QT […]
Read MoreAnesthesiology 9 2015, Vol.123, 535-541 Authors: David B. Auyong MD et al Background: Despite ultrasound guidance for central line placement, complications persist, as exact needle location is often difficult to confirm with standard two-dimension ultrasound. A novel real-time needle guidance technology has recently become available (eZono, Germany) that tracks the needle during insertion. This randomized, blinded, crossover study examined […]
Read MoreAuthors: Appelboam A et al., Lancet 2015 Aug 24; A simple modification in the Valsalva maneuver dramatically increased its effectiveness. The Valsalva maneuver is recommended first-line treatment for stable patients with supraventricular tachycardia, although it is successful in only a minority of patients. These authors tested whether a modified Valsalva maneuver can improve cardioversion rates. In a […]
Read MoreAnesthesiology 10 2015, Vol.123, 810-819 Authors: Creed M. Stary, MD, PhD et al Background: Isoflurane induces cell death in neurons undergoing synaptogenesis via increased production of pro-brain–derived neurotrophic factor (proBDNF) and activation of postsynaptic p75 neurotrophin receptor (p75NTR). Astrocytes express p75NTR, but their role in neuronal p75NTR-mediated cell death remains unclear. The authors investigated whether astrocytes have the capacity […]
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