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Anesthesia & Analgesia: April 2015 Issue 1 page 149-158 Authors: Heesen, Michael MD et al BACKGROUND: Patient-controlled epidural analgesia (PCEA) has gained popularity, but it is still unclear whether adding a background infusion confers any benefit. METHODS: A systematic literature search in PubMed, Embase, CINAHL, LILACS, CENTRAL, Clinicaltrials.gov, and ISI WOS was performed to identify […]
Read MorePublished in Anesthesia & Analgesia: May 2015 Authors: Peralta, Feyce MD et al BACKGROUND: Unintentional dural puncture is a known risk after epidural or combined spinal-epidural procedures, occurring in approximately 1% of labor epidural catheters placed in parturients with normal body habitus but may be as high as 4% in morbidly obese parturients. Anecdotal experience […]
Read MorePublished in Anesthesia & Analgesia: April 2015 Authors: Fortier, Louis-Philippe MSc, MD, FRCPC et BACKGROUND: Postoperative residual neuromuscular blockade (NMB), defined as a train-of-four (TOF) ratio of <0.9, is an established risk factor for critical postoperative respiratory events and increased morbidity. At present, little is known about the occurrence of residual NMB in Canada. The […]
Read MoreA fast-acting transdermal gel using a proprietary formulation of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen (Topofen, Achelios Therapeutics) reduced pain severity in patients with severe migraine with and without aura compared with placebo and had few adverse effects. Results from a phase 2a trial of the gel were presented here at the American Academy of […]
Read MorePublished in Anesthesia & Analgesia May 2015 Authors: Weingarten, Toby N. MD et al BACKGROUND: The aim of this study was to identify patient and procedural characteristics associated with postoperative respiratory depression or sedation requiring naloxone intervention. METHODS: We identified patients who received naloxone to reverse opioid-induced respiratory depression or sedation within 48 hours after […]
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