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Uncategorized Published - 16 October, 2015    By - Dr Clemens
FDA Approves Praxbind to Reverse Anticoagulant Pradaxa

The US Food and Drug Administration (FDA) has granted accelerated approval to Praxbind (idarucizumab, Boehringer Ingelheim) to rapidly reverse the blood-thinning effects of the anticoagulant Pradaxa (dabigatran, Boehringer Ingelheim). “The anticoagulant effects of Pradaxa are important and life-saving for some patients, but there are situations where reversal of the drug’s effects is medically necessary,” said […]

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Uncategorized Published - 16 October, 2015    By - Dr Clemens
FDA Explains Why Neurologic Events from Epidural Corticosteroids Didn’t Merit More Regulatory Action

A perspective in the New England Journal of Medicine discusses the FDA’s risk assessment of serious neurologic events associated with the off-label use of epidural glucocorticoid injections. In April 2014, the FDA required a label change for injectable corticosteroids — which are commonly used to treat neck and back pain — to warn about “rare but serious,” […]

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Uncategorized Published - 16 October, 2015    By - Dr Clemens
Acquired Muscle Weakness in the Surgical Intensive Care Unit: Nosology, Epidemiology, Diagnosis, and Prevention

Authors: Hassan Farhan, M.D. et al Anesthesiology 10 2015. Abstract Muscle weakness is common in the surgical intensive care unit (ICU). Low muscle mass at ICU admission is a significant predictor of adverse outcomes. The consequences of ICU-acquired muscle weakness depend on the underlying mechanism. Temporary drug-induced weakness when properly managed may not affect outcome. Severe […]

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Uncategorized Published - 16 October, 2015    By - Dr Clemens
Increase in Self-Harm Emergencies Noted After Bariatric Surgery

Patients undergoing bariatric surgery show a small but definite increase in self-harm emergencies after the procedure, researchers report in JAMA Surgery. Using Ontario provincial health records, the researchers compared rates of self-harm incidents in the 3 years preceding surgery versus the 3 years following it in some 8800 patients. Self-harm was measured as emergency visits for […]

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Uncategorized Published - 16 October, 2015    By - Dr Clemens
A Randomized Comparison Between Single- and Triple-Injection Subparaneural Popliteal Sciatic Nerve Block

Regional Anesthesia & Pain Medicine: July/August 2015 – Volume 40 – Issue 4 – p 315–320 Authors: Tiyaprasertkul, Worakamol MD Background and Objectives: This prospective randomized trial compared ultrasound-guided single-injection (SI) and triple-injection (TI) subparaneural popliteal sciatic nerve block. We hypothesized that multiple injections are not required when local anesthetic (LA) is deposited under the […]

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