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Uncategorized Published - 13 April, 2015    By - Dr Clemens
Ketamine vs. Morphine for Analgesia

Published in Ann Emerg Med 2015 Mar 26; Authors: Motov S et al. Subdissociative-dose ketamine was as effective as morphine for acute pain in emergency department patients. Interest in ketamine as an analgesic has been growing. To evaluate the analgesic effect and safety of ketamine in an emergency department (ED) setting, investigators conducted a randomized, […]

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Uncategorized Published - 13 April, 2015    By - Dr Clemens
Nebulized Fentanyl vs. Intravenous Morphine for Abdominal Pain

Published in Am J Emerg Med 2015 Mar 25; Authors: Deaton T et al. In a small randomized trial, nebulized fentanyl produced better pain relief and satisfaction than intravenous morphine. Fentanyl, a potent opioid with minimal hemodynamic effects, can be delivered by a variety of routes. In a randomized trial, investigators compared nebulized fentanyl (2 […]

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Uncategorized Published - 10 April, 2015    By - Dr Clemens
Blood/Gas Partition Coefficients for Isoflurane, Sevoflurane, and Desflurane in a Clinically Relevant Patient Population

Published in Anesthesia & Analgesia (Nov 2014) Authors: Esper T et al BACKGROUND: The blood/gas partition coefficient of a certain volatile anesthetic is of clinical importance because it determines its velocity of uptake into and elimination from the body of a patient and thus its pharmacokinetic behavior. To date, the blood/gas partition coefficients of isoflurane, […]

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Uncategorized Published - 10 April, 2015    By - Dr Clemens
Excessive Postoperative Bleeding and Outcomes in Neonates Undergoing Cardiopulmonary Bypass

Published in Anesthesia & Analgesia (Nov 2014) Authors: Guzzetta N et al BACKGROUND: Neonates undergoing cardiac surgery are especially prone to the hemostatic alterations of cardiopulmonary bypass (CPB) and are at high risk for post-CPB bleeding. An immature coagulation system, significant hemodilution from the CPB prime, long CPB times at low temperatures, and extensive suture […]

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Uncategorized Published - 10 April, 2015    By - Dr Clemens
Addition of tramadol to standard IV acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo-controlled trial

Published in Paediatr Anaesth Author(s): Olischar M et al. BACKGROUND Tramadol is used following neonatal cardiac and general surgery. However, its ability to opioid-spare or facilitate earlier extubation in postoperative neonates is unquantified. OBJECTIVE This randomized placebo-controlled trial aimed to assess whether tramadol’s addition to standard analgesia resulted in earlier extubation or reduced analgesic/sedative requirements […]

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