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Uncategorized Published - 30 November, 2015    By - Dr Clemens
An Expedited Care Pathway with Ambulatory Brachial Plexus Analgesia Is a Cost-effective Alternative to Standard Inpatient Care after Complex Arthroscopic Elbow Surgery: A Randomized, Single-blinded Study

Authors: Hillenn Cruz Eng, MD, et al Anesthesiology 12 2015, Vol.123, 1256-1266. Background: Common standard practice after complex arthroscopic elbow surgery includes hospital admission for 72 h. The authors hypothesized that an expedited care pathway, with 24 h of hospital admission and ambulatory brachial plexus analgesia and continuous passive motion at home, results in equivalent elbow range of […]

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Uncategorized Published - 30 November, 2015    By - Dr Clemens
Inflammation Increases Neuronal Sensitivity to General Anesthetics

Authors: Sinziana Avramescu, MD, PhD, et al Anesthesiology published on 11 2015. Background: Critically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms remain poorly understood. Inflammation increases the number of γ-aminobutyric acid type A (GABAA) receptors expressed on the surface of neurons, which supports the hypothesis that inflammation increases up-regulation […]

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Uncategorized Published - 30 November, 2015    By - Dr Clemens
Morbidity and Mortality after High-dose Transfusion

Authors: Daniel J. Johnson, B.S. el at Anesthesiology published on 11 2015. Background: It is well recognized that increased transfusion volumes are associated with increased morbidity and mortality, but dose–response relations between high- and very-high-dose transfusion and clinical outcomes have not been described previously. In this study, the authors assessed (1) the dose–response relation over a wide […]

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Uncategorized Published - 30 November, 2015    By - Dr Clemens
Impact of Perioperative Epidural Placement on Postdischarge Opioid Use in Patients Undergoing Abdominal Surgery

Authors: Karim S. Ladha, MD M.Sc et al Anesthesiology published on 11 2015. Background: Opioids play a crucial role in providing analgesia throughout the perioperative period; however, patients may become persistent users of these medications months after surgery. Epidurals have been posited to prevent the development of persistent pain, but there are little data on the effect […]

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Uncategorized Published - 27 November, 2015    By - Dr Clemens
Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

Authors: Lisbeth Evered, B.Sc, M.Biostat, PhD et al Anesthesiology published on 11 2015. Background: Postoperative cognitive dysfunction (POCD) affects 16 to 21% of the elderly 3 months after anesthesia and surgery and is associated with adverse outcomes. The exact cause of POCD remains unknown. The authors hypothesized that elderly individuals with Alzheimer disease (AD) neuropathology, identified by cerebrospinal […]

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