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Uncategorized Published - 9 November, 2015    By - Dr Clemens
Surgeons Who Operate in More Than One OR at a Time: Efficient?

In some large, academic hospitals, busy surgeons often request the concurrent use of multiple operating rooms (ORs), with the goal of increasing efficiency. In the past, the practice has been associated with increased patient time in the OR, but little if any research to date has studied the issue formally. Timothy Harwood, MD, director of […]

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Uncategorized Published - 9 November, 2015    By - Dr Clemens
The Effect of Intravenous Midazolam on Postoperative Nausea and Vomiting: A Meta-Analysis

Anesth Analg. 2015 Sep 1. Authors: Grant MC etc al BACKGROUND: Research has shown that high-risk surgical patients benefit from a multimodal therapeutic approach to prevent postoperative nausea and vomiting (PONV). Our group sought to investigate the effect of administering IV midazolam on PONV. METHODS: This meta-analysis included 12 randomized controlled trials (n = 841) of adults […]

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Uncategorized Published - 6 November, 2015    By - Dr Clemens
Promising New Opioid Has Novel Mechanism

An investigational opioid with a novel mechanism of action produced rapid pain relief in a new study. Results of a double-blind, phase 2 study of the drug (TRV130, Trevena Inc) showed that it was superior to placebo in terms of reducing pain intensity in patients undergoing a bunionectomy, relieving pain within 5 minutes of administration […]

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Uncategorized Published - 6 November, 2015    By - Dr Clemens
Renal Outcomes in Critically Ill Patients Receiving Propofol or Midazolam.

Clin J Am Soc Nephrol, 2015 Sep 4. Authors: Leite TT et al BACKGROUND AND OBJECTIVES: Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is limited to patients undergoing cardiac surgery. There are no data about its association with oliguria and AKI in critically ill patients. DESIGN, SETTING, PARTICIPANTS, & […]

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Uncategorized Published - 6 November, 2015    By - Dr Clemens
Correlation of Subjective Effects with Systemic Opioid Exposure from Fixed-Dose Combinations of Oxycodone/Acetaminophen in Recreational Users of Prescription Drugs.

Pain Med 2015 Aug 25 Authors: Morton TL et al OBJECTIVE: To correlate abuse-related pharmacodynamic measures and pharmacokinetic measures after administering immediate-release/extended-release and immediate-release oxycodone/acetaminophen fixed-dose combination analgesics DESIGN: Randomized, double-blind, active- and placebo-controlled, 7-way crossover study SETTING: Contract research organization SUBJECTS: Nondependent recreational users of prescription opioids. METHODS: Participants received single doses of intact immediate-release/extended-release and […]

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