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Uncategorized Published - 13 November, 2015    By - Dr Clemens
A randomized controlled trial of light versus deep propofol sedation for elective outpatient colonoscopy: recall, procedural conditions, and recovery.

Can J Anaesth, 2015 Nov;62(11):1169-1178. Authors: Allen M et al PURPOSE: This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, patient clinical recovery, and post-procedure cognitive impairment. METHODS: Two hundred patients undergoing elective outpatient colonoscopy were randomized to light (bispectral index [BIS] 70-80) […]

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Uncategorized Published - 13 November, 2015    By - Dr Clemens
Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report.

Can J Anaesth, 2015 Dec;62(12):1303-1307 Authors: Thanapaalasgham K et al PURPOSE: Pheochromocytomas (PHEOS) are rare catecholamine-secreting adrenal tumours requiring surgical resection. Preoperative alpha-adrenergic receptor blockade to prevent intraoperative hypertension has traditionally been achieved with phenoxybenzamine. Due to changes in the availability of phenoxybenzamine in Canada, alternate therapies are needed for patients. We report our first experience using […]

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Uncategorized Published - 13 November, 2015    By - Dr Clemens
Capsaicin 8% Patch Effective for Painful Diabetic Peripheral Neuropathy

Capsaicin 8% patch is well-tolerated and provides significant improvements in pain and sleep quality compared with placebo for patients with painful diabetic peripheral neuropathy (PDPN), according to a study presented here at the 51st Annual Meeting of the European Association for the Study of Diabetes (EASD). Capsaicin 8% patch has been used as an analgesic […]

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Uncategorized Published - 12 November, 2015    By - Dr Clemens
FDA Approves First Dabigatran Reversal Agent

The FDA has granted accelerated approval for idarucizumab (Praxbind) to reverse the anticoagulant effects of dabigatran (Pradaxa) in emergency situations. Idarucizumab, an injectable monoclonal antibody fragment, binds to dabigatran and thereby neutralizes its effect. Approval was based on three trials in which some 280 healthy adults who did not require anticoagulant therapy were given dabigatran […]

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Uncategorized Published - 12 November, 2015    By - Dr Clemens
Induced Hypothermia Can Worsen Outcomes After Traumatic Brain Injury

Authors: Andrews PJD et al., N Engl J Med 2015 Oct 7; A multicenter randomized trial was stopped early because hypothermia worsened outcomes when used as second-line therapy for elevated intracranial pressure. Induced hypothermia has become popular for treating cerebral edema from traumatic brain injury (TBI), but we do not know the effect on long-term […]

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