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Authors: Mouncey PR et al., N Engl J Med 2015 Apr 2; 372:1301 A third trial shows no benefit for early goal-directed therapy for septic shock. In 2001, a single-center randomized trial demonstrated a significant mortality benefit for early goal-directed therapy (EGDT) in patients with septic shock (NEJM JW Gen Med Dec 15 2001 and N Engl J Med 2001; […]
Read MoreOpioid-induced hyperalgesia is among the most pressing concerns in the national discussion of opioid addiction, underscored by the US Food and Drug Administration’s (FDA) call for clinical trials to better understand the risks, but the issue is mired in more complexities and confusion than many may even realize, an expert says. Norman Harden, MD, from […]
Read MoreAuthors: Paul A van Beest et al BMC Anesthesiol. 2014;14(122) Background Tissue hypoperfusion occurs frequently during surgery and may contribute to postoperative organ dysfunction. There is a need for perioperative treatment protocols aiming at improving tissue oxygenation (StO2). We hypothesised that intra-operative optimisation of StO2 improves tissue perfusion and thus reduces postoperative complications. Furthermore, we evaluated the feasibility […]
Read MorePublished in Cochrane Database Syst Rev. 2015 Mar 29 Authors: Mkontwana N et al BACKGROUND: Oral analgesia is a convenient and widely used form of pain relief following caesarean section. It includes various medications used at different doses alone or in adjunction to other form of analgesia. OBJECTIVES: To determine the effectiveness, safety and cost-effectiveness of […]
Read MoreExtended-release liposomal bupivacaine provides no benefit over standard bupivacaine for pain control after total knee replacement (TKA), according to a study presented here at the 2015 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). William C. Schroer, MD, DePaul Hospital, St. Louis, Missouri, and colleagues randomised 111 patients undergoing primary TKA to receive […]
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