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Uncategorized Published - 25 November, 2015    By - Dr Clemens
Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1

Authors: Vito Fanelli MD, PhD, et al Anesthesiology published on 11 2015. Background: Neuromuscular blocking agents (NMBAs) bind the nicotinic acetylcholine receptor α1 (nAChRα1) that also contributes to inflammatory signaling. Thus, the author hypothesized that the use of NMBA mitigates lung injury by improving ventilator synchrony and decreasing inflammatory responses. Methods: Lung injury was induced by intratracheal instillation of hydrogen […]

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Uncategorized Published - 24 November, 2015    By - Dr Clemens
Association between Intraoperative Hypotension and Myocardial Injury after Vascular Surgery

Authors: Judith A. R. van Waes, MD, et al Anesthesiology published on 11 2015. Background: Postoperative myocardial injury occurs frequently after noncardiac surgery and is strongly associated with mortality. Intraoperative hypotension (IOH) is hypothesized to be a possible cause. The aim of this study was to determine the association between IOH and postoperative myocardial injury. Methods: This cohort study […]

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Uncategorized Published - 24 November, 2015    By - Dr Clemens
Prolonged Operative Time to Extubation Is Not a Useful Metric for Comparing the Performance of Individual Anesthesia Providers

Authors:Emine Ozgur Bayman, PhD, et al Anesthesiology published on 11 2015. Background: One anesthesiologist performance metric is the incidence of “prolonged” (15 min or longer after dressing complete) times to extubation. The authors used several methods to identify the performance outliers and assess whether targeting these outliers for reduction could improve operating room workflow. Methods: Time to extubation data […]

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Uncategorized Published - 24 November, 2015    By - Dr Clemens
Major Adverse Events and Relationship to Nil per OsStatus in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Research Consortium

Authors: Michael L. Beach, MD, PhD, et al Anesthesiology published on 11 2015. Background: Studies that have attempted to define the incidence of aspiration or pulmonary complications during sedation/anesthesia of children with respect to nil per os (NPO) status or other factors are difficult because of the relatively infrequent rate of these complications. Methods: The Pediatric Sedation Research Consortium consists of […]

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Uncategorized Published - 24 November, 2015    By - Dr Clemens
Patient-controlled Analgesia with Target-controlled Infusion of Hydromorphone in Postoperative Pain Therapy

Authors: Christian Jeleazcov MD. M.Sc, et al Anesthesiology published on 11 2015 Background: Patient-controlled analgesia (PCA) is a common method for postoperative pain therapy, but it is characterized by large variation of plasma concentrations. PCA with target-controlled infusion (TCI-PCA) may be an alternative. In a previous analysis, the authors developed a pharmacokinetic model for hydromorphone. In this secondary […]

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