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Anesthesiology 9 2015, Vol.123, 618-627 Authors: Massimo Cressoni MD et al Background: During mechanical ventilation, stress and strain may be locally multiplied in an inhomogeneous lung. The authors investigated whether, in healthy lungs, during high pressure/volume ventilation, injury begins at the interface of naturally inhomogeneous structures as visceral pleura, bronchi, vessels, and alveoli. The authors wished also to […]
Read MoreAnesthesiology 9 2015, Vol.123, 548-556 Authors: Matthew A. Timmins, B.Sc, et al Background: Malignant hyperthermia (MH) is triggered by reactions to anesthetics. Reports link nonanesthetic-induced MH-like reactions to a variety of disorders. The objective of the authors was to retrospectively investigate the reasons for referrals for MH testing in nonanesthetic cases and assess their phenotype. In addition, the […]
Read MoreAuthors: Douketis JD et al., N Engl J Med 2015 Aug 27; 373:823 Perioperative “bridging” anticoagulation in warfarin-treated AF patients didn’t prevent thromboembolism but did cause excess major bleeding. In the U.S., many warfarin-treated patients with atrial fibrillation (AF) who undergo elective surgery receive perioperative bridging anticoagulation, despite a paucity of evidence supporting this practice. In this […]
Read MoreAnesthesiology 9 2015, Vol.123, 542-547 Authors: Martin Neukirchen NM et al Background: Impaired cardiac repolarization, indicated by prolonged QT interval, may cause critical ventricular arrhythmias. Many anesthetics increase the QT interval by blockade of rapidly acting potassium rectifier channels. Although xenon does not affect these channels in isolated cardiomyocytes, the authors hypothesized that xenon increases the QT […]
Read MoreAnesthesiology 9 2015, Vol.123, 535-541 Authors: David B. Auyong MD et al Background: Despite ultrasound guidance for central line placement, complications persist, as exact needle location is often difficult to confirm with standard two-dimension ultrasound. A novel real-time needle guidance technology has recently become available (eZono, Germany) that tracks the needle during insertion. This randomized, blinded, crossover study examined […]
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