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Uncategorized Published - 28 October, 2015    By - Dr Clemens
Postoperative Pain Management after Radical Cystectomy: Comparing Traditional versus Enhanced Recovery Protocol Pathway

J Urol, 2015 Nov;194(5):1209-13. doi: 10.1016/j.juro.2015.05.083. Authors: Xu W et al PURPOSE: Opioids have traditionally been the mainstay of pain management after radical cystectomy for bladder cancer but they have many side effects. The efficacy of opioid sparing analgesics after cystectomy as part of a protocol of enhanced recovery after surgery has yet to be proved. We […]

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Uncategorized Published - 28 October, 2015    By - Dr Clemens
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain

Anaesthesia 2015 Oct;70(10):1186-204. Authors: Doleman B et al Abstract We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until December 2014 and included 133 randomised controlled trials of peri-operative gabapentin vs placebo. Gabapentin reduced mean (95% CI) 24-h morphine-equivalent consumption by 8.44 (7.26-9.62) mg, p < 0.001, whereas more specific reductions in morphine equivalents were predicted (R(2)  = 90%, p < 0.001) […]

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Uncategorized Published - 28 October, 2015    By - Dr Clemens
Should We Restrict Erythrocyte Transfusion in Early Goal Directed Protocols?

Authors: Patrick Meybohm et al BMC Anesthesiol. 2015;15(75) Background: Early goal-directed therapy has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy among patients presenting with severe sepsis or septic shock. But more importantly, early goal-directed therapy also became standard care for non-septic critically ill patients and was adopted for high-risk surgical […]

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Uncategorized Published - 28 October, 2015    By - Dr Clemens
Safety and Efficacy of Combined Epidural/General Anesthesia During Major Abdominal Surgery in Patients With Increased Intracranial Pressure

Authors: Igor Zabolotskikh et al BMC Anesthesiol. 2015;15(76) Background: The increased intracranial pressure can significantly complicate the perioperative period in major abdominal surgery, increasing the risk of complications, the length of recovery from the surgery, worsening the outcome. Epidural anesthesia has become a routine component of abdominal surgery, but its use in patients with increased intracranial pressure […]

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Uncategorized Published - 27 October, 2015    By - Dr Clemens
CDC: Multiple Naloxone Doses May Be Needed for Fentanyl Overdoses

Multiple doses of naloxone may be needed to revive a patient after a fentanyl overdose, given fentanyl’s higher potency compared with other opioids, the CDC advised healthcare providers on Monday. In particular, nonpharmaceutical fentanyl — that is, illegally manufactured fentanyl and its analogs, often mixed with heroin or cocaine — tends to be especially potent. […]

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