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Anesthesia & Analgesia: April 15, 2016 AUTHORS: Zaphiratos, Valerie MD, MSc, FRCPC et al BACKGROUND: Combined spinal-epidural (CSE) analgesia is widely used for delivering labor analgesia. Epidural volume extension (EVE) involves the injection of fluid into the epidural space compressing the dural sac, causing cephalad shift of the cerebral spinal fluid. Our hypothesis was that […]
Read MoreAnesthesia & Analgesia: April 15, 2016 AUTHORS: Bang, Ji-Yeon MD, PhD et al BACKGROUND: Acute kidney injury (AKI) is a primary cause of morbidity and mortality after major abdominal surgery; however, little is known about the effect of anesthetics on the development of AKI after colorectal surgery. The objective of this study was to compare […]
Read MoreAuthors: M Narayanan MB BS MD FRCA FCARCSI EDIC EDRA et al BJA Education. 2016;16(2):72-78. Introduction Patients in intensive care experience distress because of a multitude of factors and a significant proportion is attributable to pain.[1] A vast majority of patients report moderate to severe pain at some point during their intensive care stay. Pain can be […]
Read MoreStudy finds fentanyl transdermal patches are too often prescribed to opioid-naïve and elderly patients, raising their risks of fatal adverse drug events. Interview with Caleb Alexander, MD Fentanyl patches are a highly potent options for cancer and non-cancer pain patients, but are contraindicated in opioid naïve patients. However, new research indicates that physicians may be […]
Read MoreAnesthesia & Analgesia: May 17, 2016 AUTHORS: Zentai, Christian MD et al BACKGROUND: The potential clinical benefits of targeted therapy with coagulation factor concentrates (e.g., fibrinogen) and antifibrinolytic agents (e.g., tranexamic acid [TXA]) for the treatment of trauma-induced coagulopathy are increasingly recognized. We hypothesized that human fibrinogen concentrate (FC) and prothrombin complex concentrate (PCC), administered […]
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