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Uncategorized Published - 11 May, 2016    By - Dr Clemens
Effect of Exogenous Albumin on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Off-pump Coronary Artery Bypass Surgery with a Preoperative Albumin Level of Less Than 4.0 g/dl

Authors: Eun-Ho Lee, M.D. et al  Anesthesiology 5 2016, Vol.124, 1001-1011 Background: Hypoalbuminemia may increase the risk of acute kidney injury (AKI). The authors investigated whether the immediate preoperative administration of 20% albumin solution affects the incidence of AKI after off-pump coronary artery bypass surgery. Methods: In this prospective, single-center, randomized, parallel-arm double-blind trial, 220 patients with preoperative […]

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Uncategorized Published - 11 May, 2016    By - Dr Clemens
Fentanyl Patches Overused in Vulnerable Populations

Study finds fentanyl transdermal patches are too often prescribed to opioid-naïve and elderly patients, raising their risks of fatal adverse drug events. Interview with Caleb Alexander, MD Fentanyl patches are a highly potent options for cancer and non-cancer pain patients, but are contraindicated in opioid naïve patients. However, new research indicates that physicians may be […]

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Uncategorized Published - 10 May, 2016    By - Dr Clemens
Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning

Authors: Andrew P. Wojtovich, Ph.D. et al  Anesthesiology 5 2016, Vol.124, 1065-1076. Background: Anesthetic preconditioning (APC) is a clinically important phenomenon in which volatile anesthetics (VAs) protect tissues such as heart against ischemic injury. The mechanism of APC is thought to involve K+ channels encoded by the Slo gene family, and the authors showed previously that slo-2 is required for APC inCaenorhabditis […]

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Uncategorized Published - 10 May, 2016    By - Dr Clemens
OxyContin Fails to Deliver 12 Hours of Pain Relief in Many

Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Contrary to its marketing claims, OxyContin’s pain-relieving effects often fall short of 12 hours in many patients, which can lead to a host of other problems, according to an investigation by the Los Angeles Times. OxyContin is approved for 12-hour dosing. Several studies found that the drug’s effects […]

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Uncategorized Published - 10 May, 2016    By - Dr Clemens
How Market Forces Can Affect Patient Safety: The Unintended Consequences of Capitalism in the Generic Drug Market

Authors: Roy G. Soto, M.D. et al ASA Monitor 05 2016, Vol.80, 28-29. First off, let’s agree on two basic concepts: capitalism is good and patient safety is good. For decades we have been tempted with a never-ending parade of new, expensive devices and medications that are touted to improve safety and outcomes. Sometimes the acquisition cost […]

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