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Uncategorized Published - 13 July, 2016    By - Dr Clemens
Dexketoprofen/Tramadol 25 Mg/75 Mg

Authors: R. A. Moore et al BMC Anesthesiol. 2016;16(9) Background: Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms of action for the treatment of moderate to severe acute pain. Methods: Randomised, double-blind, parallel, placebo and active-controlled, single and multiple-dose study to evaluate the analgesic efficacy and safety of dexketoprofen/tramadol […]

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Uncategorized Published - 13 July, 2016    By - Dr Clemens
Pain Management Strategies for Neuropathic Pain in Fabry Disease

Authors: Y. Schuller et al BMC Neurol. 2016;16(25) Background: Neuropathic pain is one of the key features of (classical) Fabry disease (FD). No randomized clinical trials comparing effectiveness of different pain management strategies have been performed. This review aims to give an overview of existing pain management strategies. Methods: PubMed and Embase were searched up to September 2014 […]

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Uncategorized Published - 13 July, 2016    By - Dr Clemens
Should Naloxone Be Prescribed for Patients Taking Opioids for Chronic Pain?

Authors: Walley AY and Green TC., Ann Intern Med 2016 Jun 28; Coprescribing naloxone was associated with fewer opioid-related emergency room visits. Many communities that use targeted distribution of the short-acting opioid antagonist naloxone to reverse unintentional opioid overdoses have seen declines in community-level opioid overdose–related mortality. In this observational study from six “safety net” clinics in […]

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Uncategorized Published - 13 July, 2016    By - Dr Clemens
Buprenorphine: Implants at Least as Effective as Sublingual Tablets for Opioid Dependence

Buprenorphine implants are at least as effective as sublingual buprenorphine as a maintenance treatment for opioid dependence, according to a noninferiority trial in JAMA. Roughly 175 adults who were clinically stable on sublingual buprenorphine were randomized to receive four buprenorphine implants plus sublingual placebo or four placebo implants plus sublingual buprenorphine. The primary endpoint — the […]

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Uncategorized Published - 12 July, 2016    By - Dr Clemens
A Multicenter, Randomized, Controlled Phase IIb Trial of Avoidance of Hyperoxemia during Cardiopulmonary Bypass

Authors: Shay P. McGuinness, M.B.Ch.B. et al Anesthesiology published on 7 2016 Background: Cardiac surgery utilizing cardiopulmonary bypass (CPB) is one of the most common forms of major surgery. Cardiac surgery–associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. Pathophysiology of CSA-MOD involves numerous injurious […]

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