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Anesthesiologists who use perioperative clonidine in the hope of reducing acute postoperative pain or opioid consumption need to reconsider their efforts. According to a randomized controlled trial at the Cleveland Clinic, in Ohio—the largest such trial ever—researchers found that the drug has neither of these perceived benefits, and its use may come at the expense […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 547–550 AUTHORS: Sentissi, Kinza MD et al In this prospective observational study, conducted at an academic medical center, we evaluated the feasibility of performing a basic transesophageal echocardiography (TEE) examination using endoscopic ultrasound (EUS) technology to determine what cardiac structures could be […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 535–546 AUTHORS: Mitrophanov, Alexander Y. PhD et al BACKGROUND: The use of prothrombin complex concentrates in trauma- and surgery-induced coagulopathy is complicated by the possibility of thromboembolic events. To explore the effects of these agents on thrombin generation (TG), we investigated combinations […]
Read MoreAnesthesia & Analgesia: September 2016 – Volume 123 – Issue 3 – p 570–577 AUTHORS: Fabbro, Michael II DO et al BACKGROUND: The inflated costs and documented deleterious effects of excess perioperative transfusion have led to the investigation of targeted coagulation factor replacement strategies. One particular coagulation factor of interest is factor I (fibrinogen). Hypofibrinogenemia […]
Read MoreA study published in PLOS ONE shows that symptoms of chronic fatigue syndrome can be provoked by imposing a mild to moderate strain to the muscles and nerves. The study included 80 individuals, 60 with CFS and 20 without CFS, who reported their levels of fatigue, body pain, lightheadedness, concentration difficulties, and headache every 5 […]
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