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Anesthesia & Analgesia: August 31, 2016 AUTHORS: Suresh, Santhanam MD et al BACKGROUND: We evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. METHODS: Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, […]
Read MorePatients with implanted devices for spinal cord stimulation (SCS) for whom paresthesia-based stimulation has failed to relieve pain may have an “effective alternative” in subperception stimulation at 1 kHz, a recent pilot study suggests. The investigators conducted a prospective, randomized study (Neuromodulation2016 May 17. [Epub ahead of print]) to apply the findings of a study […]
Read MoreFor the antifibrinolytic agent tranexamic acid, doses varying between 5 and 15 mg/kg failed to produce a dose-dependent drop in hemoglobin after total knee (TKA) or total hip arthroplasty (THA), leading study investigators to recommend using the lowest of these doses in orthopedic patients. “At my institution, we reviewed quite a bit of data while […]
Read MoreAnil Patel, MD, FRCA Consultant Anaesthetist Royal National Throat, Nose and Ear Hospital University College London Hospitals NHS Foundation Trust London, United Kingdom S.A. Reza Nouraei, MBBChir, PhD, FRCS Ear, Nose, and Throat Surgeon Honorary Senior Lecturer in Otolaryngology, University College London London, United Kingdom High-flow nasal oxygen optimizes preoxygenation and apnea time compared with […]
Read MoreThe US Food and Drug Administration (FDA) review has found that the growing combined use of opioid medicines with benzodiazepines or other drugs that depress the central nervous system (CNS) has resulted in serious side effects, including slowed or difficult breathing and deaths. In an effort to decrease the use of opioids and benzodiazepines, or […]
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