Opioids are widely used in the United States to manage moderate to severe acute postoperative pain, but adverse events, including respiratory depression and gastrointestinal dysfunction, can limit the dosing required for analgesic efficacy. Oliceridine—a novel mu-receptor G protein pathway selective modulator—may provide effective, rapid analgesia and reduce typical adverse effects, according to two recent Phase […]
Read MoreAnesthesia & Analgesia: October 2016 – Volume 123 – Issue 4 – p 1004–1007 AUTHORS: Karlsson, Victoria RN, MMSc et al BACKGROUND: Transcutaneous (TC) measurement of PCO2 (TC PCO2) is a well-established method to monitor assisted ventilation in neonatal intensive care, but its use in the operating room is limited, and the data regarding its performance […]
Read MoreAnesthesia & Analgesia: October 2016 – Volume 123 – Issue 4 – p 991–1003 AUTHORS: Hayes, Jason MD et al BACKGROUND: Bolus administration of opioids via a patient-controlled analgesia (PCA) device is widely used in the postoperative pediatric population. PCA devices have been shown to provide superior analgesia and greater patient satisfaction compared with intermittent […]
Read MoreRepeated use of general anesthetic and sedation drugs — or use for longer than 3 hours — in children under age 3 years and in pregnant women in their third trimester could adversely affect child brain development, the FDA warned on Wednesday. The agency cited animal data showing that early, lengthy exposure to these drugs […]
Read MoreAnesthesia & Analgesia: October 2016 – Volume 123 – Issue 4 – p 972–976 AUTHORS: Orbach-Zinger, Sharon MD et al BACKGROUND: Unintended dural puncture (UDP) is one of the main risks of epidural analgesia, with a reported incidence of approximately 1.5% among the obstetric population. UDP is associated with maternal adverse outcomes, with the most […]
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