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Uncategorized Published - 3 February, 2017    By - Dr Clemens
Intravenous Amisulpride for the Prevention of Postoperative Nausea and Vomiting: Two Concurrent, Randomized, Double-blind, Placebo-controlled Trials

Authors: Tong J. Gan, M.D. et al      Anesthesiology 2 2017, Vol.126, 268-275. Background: Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. Methods: Adult inpatients undergoing elective surgery during general anesthesia and having at […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room

Authors: Matthieu Biais, M.D., Ph.D. et al Anesthesiology 2 2017, Vol.126, 260-267. Background: Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Methods: Twenty-eight mechanically ventilated patients with low tidal volume during general […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Arterial Pressure Variation in Elective Noncardiac Surgery: Identifying Reference Distributions and Modifying Factors

Authors: Michael R. Mathis, M.D. et al Anesthesiology 2 2017, Vol.126, 249-259 Background: Assessment of need for intravascular volume resuscitation remains challenging for anesthesiologists. Dynamic waveform indices, including systolic and pulse pressure variation, are demonstrated as reliable measures of fluid responsiveness for mechanically ventilated patients. Despite widespread use, real-world reference distributions for systolic and pulse pressure variation […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Safety of Perioperative Glucocorticoids in Elective Noncardiac Surgery: A Systematic Review and Meta-analysis

Authors: Andrew J. Toner, F.R.C.A. et al       Anesthesiology 2 2017, Vol.126, 234-248. Background: Glucocorticoids are increasingly used perioperatively, principally to prevent nausea and vomiting. Safety concerns focus on the potential for hyperglycemia and increased infection. The authors hypothesized that glucocorticoids predispose to such adverse outcomes in a dose-dependent fashion after elective noncardiac surgery. Methods: The authors conducted […]

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Uncategorized Published - 2 February, 2017    By - Dr Clemens
Impact of Methylprednisolone on Postoperative Quality of Recovery and Delirium in the Steroids in Cardiac Surgery Trial: A Randomized, Double-blind, Placebo-controlled Substudy

Authors: Colin F. Royse, M.B.B.S., M.D., F.A.N.Z.C.A. et al   Anesthesiology 2 2017, Vol.126, 223-233. Background: Inflammation after cardiopulmonary bypass may contribute to postoperative delirium and cognitive dysfunction. The authors evaluated the effect of high-dose methylprednisolone to suppress inflammation on the incidence of delirium and postoperative quality of recovery after cardiac surgery. Methods: Five hundred fifty-five adults from […]

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