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In adult patients undergoing internal fixation of a fracture of the femur, anterior 3-in-1 femoral block and posterior lumbar plexus block have been found to provide comparable analgesia in a recent clinical study. Although the anterior approach resulted in a higher percentage of incomplete blockade, pain scores and opioid requirements did not differ significantly from […]
Read MoreDo individual anesthesiologists directly affect patient outcomes? For years, anesthesiologists have attempted to answer this question empirically. Now, a recent study has concluded that anesthesiologists do affect outcomes, and at a rate similar to that of surgeons. “Despite everything that’s happened with surgical improvement over the years, we still see troubling rates of complications and […]
Read MoreAuthors: Viviane S. Hambrecht-Wiedbusch, Ph.D. et al Background: Promoting arousal by manipulating certain brain regions and/or neurotransmitters has been a recent research focus, with the goal of trying to improve recovery from general anesthesia. The current study tested the hypothesis that a single subanesthetic dose of ketamine during isoflurane anesthesia would increase cholinergic tone in […]
Read MoreEdited by André Sofair, MD, MPH The number of drug overdose deaths in the U.S. has more than doubled since 1999 — from 6.1 to 16 per 100,000 population. Specifically, recent increases have been seen in deaths from heroin and synthetic opioids like fentanyl, according to new CDC data. In 2015, the most recent year […]
Read MoreAuthors: Po-Kuan Chao, Ph.D. et al Anesthesiology February 23, 2017. Background: The authors investigated the pharmacology and signaling pathways of the opioid receptors modulated by compound 1, 1-(2,4-dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one. Methods: In vitro studies of compound 1 were assessed by using a radioligand-binding assay (n = 3), a cyclic adenosine monophosphate assay (n = 3), a β-arrestin […]
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