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Anesthesia & Analgesia · February 8, 2017 Authors: Matthew A et al Background: Critically ill patients frequently receive plasma transfusion under the assumptions that abnormal coagulation test results confer increased risk of bleeding and that plasma transfusion will decrease this risk. However, the effect of prophylactic plasma transfusion remains poorly understood. The objective of this study was to […]
Read MoreSouthwest Journal of Pulmonary & Critical Care · January 28, 2017 Original Article A new term has been coined by the CDC, ventilator-associated events (VAEs) (1). In 2011, the CDC convened a working group composed of members of several stakeholder organizations to address the limitations of the definition of ventilator-associated pneumonia (VAP) definition (2). The organizations represented in […]
Read MoreBJA: British Journal of Anaesthesia · February 10, 2017 Background: Predictive performance of eleven published propofol pharmacokinetic models was evaluated for long-duration propofol infusion in children. Methods: Twenty-one aged three–11 yr ASA I–II patients were included. Anaesthesia was induced with propofol or sevoflurane, and maintained with propofol, remifentanil, and fentanyl. Propofol was continuously infused at rates of 4–14 mg […]
Read MoreWhen it comes to mitigating against postoperative cognitive decline and preserving functional brain connectivity after circulatory arrest for aortic arch surgery, deep hypothermia is superior to high-moderate hypothermia, a pilot study has concluded. A larger prospective trial is underway to confirm these results. “Deep hypothermia—which constitutes cooling the body to a temperature of less than […]
Read MoreAuthors: Kawazoe Y et al., JAMA 2017 Apr 4; 317:1321 Patients with sepsis had similar outcomes when sedated with or without dexmedetomidine. Multiple recent trials have yielded mixed results on whether dexmedetomidine for sedation during mechanical ventilation prevents delirium. Interestingly, however, one such study suggested markedly lower mortality in septic patients who were sedated with dexmedetomidine (Crit Care […]
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