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Uncategorized Published - 25 April, 2025    By - Dr Clemens
Detection and Evaluation of Procalcitonin Variants As Diagnostic Tools in Systemic Inflammation

AUTHORS: Kintrup, Sebastian MD et al Anesthesia & Analgesia 140(5):p 1073-1082, May 2025. BACKGROUND: Procalcitonin is an indicator of systemic inflammation associated with major surgery or sepsis. Procalcitonin exists in a full-length and truncated variant as a result of dipeptidylpeptidase-4 (DPP4)-cleavage. We recently identified differential biological activity of both variants. Here, we present an immunoassay-based method […]

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Uncategorized Published - 25 April, 2025    By - Dr Clemens
Racial and Ethnic Underserved Populations Prescription Analgesic Use Before and After Lower Extremity Amputation in US Medicare

AUTHORS: Yang, Seonkyeong PhD et al Anesthesia & Analgesia 140(5):p 1205-1215, May 2025. BACKGROUND: Racial disparities exist in access to health care and management of multiple health conditions including chronic pain; however, racial disparities in pre- and postoperative pain management in lower extremity amputation are not well-studied. Our objective was to examine the association between different […]

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Uncategorized Published - 24 April, 2025    By - Dr Clemens
A New Method for Comprehensive Analysis of Benzodiazepine, Opioid, and Propofol Interactions and Dose Selection Rationales in Gastrointestinal Endoscopy Sedation

AUTHORS: Liou, Jing-Yang MD, PhD et al Anesthesia & Analgesia 140(5):p 1168-1177, May 2025. BACKGROUND: The aim of this study was to explore a new method for determining optimal dosing regimens for combinations of propofol, midazolam, and an opioid to achieve rapid on- and off-set of deep sedation. METHODS: We simulated 16 published dosing regimens using […]

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Uncategorized Published - 24 April, 2025    By - Dr Clemens
Assisted Fluid Management and Sublingual Microvascular Flow During High-Risk Abdominal Surgery

AUTHORS: Coeckelenbergh, Sean MD et al Anesthesia & Analgesia 140(5):p 1149-1158, May 2025. BACKGROUND: Implementation of goal-directed fluid therapy (GDFT) protocols remains low. Protocol compliance among anesthesiologists tends to be suboptimal owing to the high workload and the attention required for implementation. The assisted fluid management (AFM) system is a novel decision support tool designed to […]

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Uncategorized Published - 24 April, 2025    By - Dr Clemens
Electroencephalographic Measures of Delirium in the Perioperative Setting

Authors: Bruzzone, Maria J. MD, MSCR et al  Anesthesia & Analgesia 140(5):p 1127-1139, May 2025. | Abstract Postoperative delirium (POD) is frequent in older adults and is associated with adverse cognitive and functional outcomes. In the last several decades, there has been an increased interest in exploring tools that easily allow the early recognition of patients at […]

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