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Uncategorized Published - 19 February, 2018    By - Dr Clemens
You’re wrong. Pain is not a vital sign.

Author: MYLES GART, MD After years of exaggeration, misinformation and a national epidemic of opioid and heroin abuse, the nation is finally coming to terms with the fact that pain is not the fifth vital sign. This heresy, as I understand it, has existed for close to three decades and, in my opinion, has been […]

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Uncategorized Published - 16 February, 2018    By - Dr Clemens
FDA Updates Naloxegol Labeling for Opioid-Induced Constipation to Include Prior Cancer Indication

The FDA has updated the indication of naloxegol (Movantik, AstraZeneca) tablets for the treatment of opioid-induced constipation (OIC) in adult patients with chronic noncancer pain to include patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage escalation. This label update follows initial FDA approval for naloxegol in 2014 […]

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Uncategorized Published - 16 February, 2018    By - Dr Clemens
Nerve Block Combos Found Best for TKA Patients Post-op

The best approach to balancing analgesia, opioid use and passive range of motion after total knee arthroplasty (TKA) is to block multiple nerves rather than any single nerve, according to a sophisticated network meta-analysis. This approach proved better than periarticular local anesthetic infiltration and epidural analgesia. “Based on available evidence, we found that combinations of […]

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Uncategorized Published - 16 February, 2018    By - Dr Clemens
Dexmedetomidine Maintains Its Direct Cardioprotective Effect Against Ischemia/Reperfusion Injury in Hypertensive Hypertrophied Myocardium

AUTHORS: Yoshikawa, Yusuke MD et al Anesthesia & Analgesia: February 2018 – Volume 126 – Issue 2 – p 443–452 BACKGROUND: Dexmedetomidine (DEX) has a direct cardioprotective effect against ischemia/reperfusion injury through endothelial nitric oxide synthase (eNOS) phosphorylation via α2-adrenoreceptor (α2-AR). By using spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rat models, the cardioprotective effect of DEX […]

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Uncategorized Published - 16 February, 2018    By - Dr Clemens
Effect of an Intravenous Dexamethasone Added to Caudal Local Anesthetics to Improve Postoperative Pain: A Systematic Review and Meta-analysis With Trial Sequential Analysis

AUTHORS: Kawakami, Hiromasa MD et al Anesthesia & Analgesia: December 2017 – Volume 125 – Issue 6 – p 2072–2080 BACKGROUND: Caudal anesthesia has been used for postoperative pain control in pediatric surgical patients, but the duration of the analgesic effect is occasionally unsatisfactory. Intravenous steroids have been shown to be effective for postsurgical pain management after […]

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