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Off-label, epidural use of Depo-Medrol (methylprednisolone acetate) injections for back pain is increasing as clinicians limit their opioid prescribing — but the treatment is risky and often ineffective — the New York Times reports. Depo-Medrol’s manufacturer, Pfizer, requested in 2013 that epidural use be banned owing to risks for blindness, paralysis, stroke, and death. The FDA declined […]
Read MoreAuthors: Weick, Jack, MD et al Journal of Bone and Joint Surgery: July 18, 2018 – Volume 100 – Issue 14 – p 1171-1176 Background: Prescription opioid use is epidemic in the U.S. Recently, an association was demonstrated between preoperative opioid use and increased health-care utilization following abdominal surgeries. Given that primary total knee arthroplasty (TKA) and […]
Read MoreScience Daily August 2018 Twenty patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease, according to a study published today in Annals of Internal Medicine. The researchers also report that the kidney transplants for these 20 patients are functioning […]
Read MoreAuthors: William A. Grobman, M.D. et al N Engl J Med 2018; 379:513-523 The perinatal and maternal consequences of induction of labor at 39 weeks among low-risk nulliparous women are uncertain. METHODS In this multicenter trial, we randomly assigned low-risk nulliparous women who were at 38 weeks 0 days to 38 weeks 6 days of […]
Read MoreThe Jury Is Still Out Elizabeth L. Whitlock, MD, MSc1 et al JAMA Surg published online August 8, 2018. Perioperative delirium is an incredibly complex multifactorial syndrome, which despite a rapidly growing body of inquiry into its risk factors remains one of the most common complications of surgery and anesthesia. Acknowledging that most risk factors, such as underlying […]
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