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N.H. Sperna Weiland et al,Authors: N. H,Background The baroreflex regulates arterial blood pressure (BP). During periods when blood pressure changes, cerebral blood flow (CBF) is kept constant by cerebral autoregulation (CA). In patients with diabetes mellitus (DM), low baroreflex sensitivity (BRS) is associated with impaired CA. As sevoflurane-based anaesthesia obliterates BRS, we hypothesised that this […]
Read MoreThe FDA has approved fremanezumab (marketed as Ajovy) to prevent migraine in adults. The injectable drug, given monthly or quarterly, is a humanized monoclonal antibody that targets calcitonin gene-related peptide. In phase III trials among adults with disabling migraine, fremanezumab reduced the number of monthly migraine days over 12 weeks relative to placebo. It was […]
Read MoreAuthors: S. Boet et al British Journal of Anesthesia Sept 2018 Background Non-technical skills, such as communication or leadership, are integral to clinical competence in anaesthesia. There is a need for valid and reliable tools to measure anaesthetists’ non-technical performance for both initial and continuing professional development. This systematic review aims to summarise the measurement […]
Read MoreA commonly used painkiller might be too risky for people to keep taking, suggests a new study published this week in the BMJ. It found that people who use diclofenac, a non-steroidal anti-inflammatory drug (NSAID), are more likely to come down with cardiovascular disease than people who take other NSAIDs or acetaminophen. Diclofenac is sold under […]
Read MoreAuthors: Zannad F et al. N Engl J Med 2018 Aug 27 A randomized trial found no improvement in outcomes with low-dose rivaroxaban. Chronic anticoagulation in patients with heart failure and reduced ejection fraction (HFrEF), but without atrial fibrillation (Afib, AF), has long been controversial; clinical trials have not demonstrated any benefit of warfarin use. This […]
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