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Neither typical nor atypical antipsychotics proved more effective than placebo in shortening the duration of delirium in intensive care units, according to a New England Journal of Medicine study presented at the European Society of Intensive Care Medicine’s Annual Congress. In the multicenter study, nearly 600 patients developing delirium in the ICU underwent randomization to intravenous doses […]
Read MoreThe IRIS Randomized Clinical Trial Authors: Aurélie Birenbaum, MD et al JAMA Surg. October 17, 2018. Question Does the cricoid pressure prevent pulmonary aspiration in patients undergoing rapid sequence induction of anesthesia? Findings In this randomized, noninferiority double-blind trial involving 3472 patients, the results failed to demonstrate the noninferiority of a sham procedure in preventing pulmonary aspiration compared with the cricoid […]
Read MoreErenumab helps prevent migraine in adults who haven’t responded to other preventive treatments, according to an industry-funded study in The Lancet. The monoclonal antibody targets calcitonin gene-related peptide; it was approved in May for migraine prevention. Roughly 250 adults with episodic migraine who’d been treated unsuccessfully with two to four preventives were randomized to receive two […]
Read MoreAuthors: Carspecken, Charles William, MD, MSc, MBA et al Journal of Neurosurgical Anesthesiology: October 2018 – Volume 30 – Issue 4 – p 305–313 Background: Although interest in ketamine use during electroconvulsive therapy (ECT) has increased, studies have been equivocal with regard to its efficacy. The aims of this clinical trial were to evaluate ketamine’s antidepressive effects in ECT as a primary […]
Read MoreAuthor: Arnoley S. Abcejo, MD; Jeffrey J. Pasternak, MD apsf Newsletter Vol 33 No. 2 Oct 2018 SUMMARY:Concussion and its short and long-term cognitive consequences have garnered much publicity over the past decade. Whereas multiple concussions may be associated with long-term cognitive consequences, a single concussion has been shown to cause significant neurophysiologic changes that […]
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