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Uncategorized Published - 15 January, 2019    By - Dr Clemens
US cancer death rate hits milestone: 25 years of decline

Authors: MIKE STOBBE The U.S. cancer death rate has hit a milestone: It’s been falling for at least 25 years, according to a new report. Lower smoking rates are translating into fewer deaths. Advances in early detection and treatment also are having a positive impact, experts say. But it’s not all good news. Obesity-related cancer deaths […]

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Uncategorized Published - 15 January, 2019    By - Dr Clemens
Sublingual Sufentanil May Be Safe and Effective for Short-Term Acute Pain Management

Sufentanil sublingual tablets (SST) may be effective for the short-term postoperative or emergency department (ED) management of moderate to severe pain in patients with all body mass index (BMI) levels, according to a study to be presented at the 2018 World Congress on Pain in Boston, Massachusetts. Investigators recently submitted a New Drug Application for SST 30 […]

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Uncategorized Published - 15 January, 2019    By - Dr Clemens
Effectiveness of a multistate quality improvement campaign in reducing risk of surgical site infections following hip and knee arthroplasty

Authors: Michael S Calderwood et al BMJ Dec 2018 Background Quality improvement (QI) campaigns appear to increase use of evidence-based practices, but their effect on health outcomes is less well studied. Objective To assess the effect of a multistate QI campaign (Project JOINTS, Joining Organizations IN Tackling SSIs) that used the Institute for Healthcare Improvement’s Rapid Spread […]

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Uncategorized Published - 15 January, 2019    By - Dr Clemens
United States State-Level Variation in the Use of Neuraxial Analgesia During Labor for Pregnant Women

Alexander J. Butwick, MBBS, FRCA, MS et al  JAMA Netw Open. 2018;1(8) Question  Does the prevalence of neuraxial labor analgesia vary across US states? Findings  In this population-based, cross-sectional analysis of 2 625 950 pregnant women who underwent labor, Maine had the lowest adjusted neuraxial analgesia prevalence (36.6%) and Nevada the highest (80.1%). The odds of receiving neuraxial analgesia were 1.5-fold higher […]

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Uncategorized Published - 14 January, 2019    By - Dr Clemens
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

Authors: De Gregorio, Danilo et al PAIN: January 2019 – Volume 160 – Issue 1 – p 136–150 Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. However, its effects on 5-HT neuronal activity, as well as its impact on models of neuropathic pain are […]

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